Whole blood choline and plasma choline in acute coronary syndromes:: Prognostic and pathophysiological implications
Whole blood choline and plasma choline in acute coronary syndromes:: Prognostic and pathophysiological implications
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DOI：
10.1016/j.cca.2007.05.001
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发表时间：
2007-08-01
影响因子：
5
通讯作者：
Moeckel, Martin
中科院分区：
文献类型：
--
作者：
Danne, Oliver;Lueders, Christian;Moeckel, Martin
背景资料：急性冠状动脉综合征（ACS）患者在磷脂酶D刺激后，全血胆碱（WBCHO）和血浆胆碱（PLCHO）浓度迅速升高。对217例疑似ACS且入院肌钙蛋白T阴性的患者进行早期风险分层分析（= 28.2 μ mol/L）可预测MACE（风险比[HR] 2.7; p< 0.001），心源性死亡/心脏骤停（HR 4.2; p=0.015）、心力衰竭（HR 2.8; p=0.003）、冠状动脉介入治疗（HR 2.1; p=0.01）和MI（HR 8.4; p=0.002）。PLCHO（>= 25.0 μ mol/L）可预测MACE（HR 2.6; p=0.005）、心源性死亡/停搏（HR 15.7; p
Background: Whole blood choline (WBCHO) and plasma choline (PLCHO) concentrations increase rapidly after stimulation of phospholipase D in acute coronary syndromes (ACS). Early risk-stratification was analyzed in 217 patients with suspected ACS and a negative admission troponin T (= 28.2 mu mol/L) was predictive for MACE (hazard ratio [HR] 2.7; p< 0.001), cardiac death/arrest (HR 4.2; p=0.015), heart failure (HR 2.8; p=0.003), coronary intervention (HR 2.1; p=0.01) and MI (HR 8.4; p=0.002) after 30 days. PLCHO ( >= 25.0 mu mol/L) was predictive for MACE (HR 2.6; p=0.005), cardiac death/arrest (HR 15.7; p