REVERSIBLE OSMOTIC OPENING OF BLOOD-BRAIN BARRIER
REVERSIBLE OSMOTIC OPENING OF BLOOD-BRAIN BARRIER
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DOI：
10.1126/science.173.4001.1026
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发表时间：
1971-01-01
期刊：
影响因子：
56.9
通讯作者：
KLATZO, I
中科院分区：
文献类型：
--
作者：
RAPOPORT, SI;HORI, M;KLATZO, I
血脑屏障的可逆破坏是由一类电解质和非电解质产生的，这些电解质和非电解质几乎没有或没有脂溶性，但化学和离子性质不同。这些药物可以渗透收缩屏障细胞，可能是血管内皮，并可逆地打开它们之间的空间。脂溶性非电解质会不可逆地损害屏障。
Reversible breakdown of the blood-brain barrier is produced by a class of electrolytes and nonelectrolytes which have little or no lipid solubility but which differ in chemical and ionic properties. These agents may osmotically shrink barrier cells, possibly the vascular endothelium, and reversibly open spaces between them. Lipid-soluble nonelectrolytes damage the barrier irreversibly.