Cholesterol-lowering nature of unsaturated fat in rats may be due to its inability to increase hepatic iron
Cholesterol-lowering nature of unsaturated fat in rats may be due to its inability to increase hepatic iron
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DOI：
10.1016/s0026-0495(99)90034-3
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发表时间：
1999-02-01
影响因子：
9.8
通讯作者：
Lewis, CG
中科院分区：
文献类型：
--
作者：
Fields, M;Lewis, CG
本研究旨在确定饱和脂肪的升胆固醇特性和不饱和脂肪的降胆固醇特性是否与肝脏铁水平相关。肝铁潴留的幅度被操纵喂养大鼠的饮食，无论是铜缺乏或足够的，铁足够或补充，并含有牛脂或玉米油。根据膳食脂肪的类型（牛脂或玉米油）和膳食铜（0.74或6.9 μ g Cu/g膳食）或铁（44.4或86.7 μ g Fe/g膳食）的水平，将断奶雄性Sprague-Dawley大鼠随机分为8个膳食组。牛油和铜缺乏单独增加肝脏铁水平，这反过来又与血浆胆固醇增加。当这三种饮食因素相结合时，即铁，牛油和铜缺乏，它们诱导了最高程度的肝脏铁潴留，这反过来又与血浆胆固醇的最高浓度相关。相反，当肝脏铁潴留不增加时，例如通过喂养含有玉米油的饮食或通过消耗铜充足的饮食，血浆胆固醇没有升高。基于这些数据，建议具有增加肝脏铁的能力的营养素具有增加血浆胆固醇的潜力。版权所有（C）1999 W.B.桑德斯公司
The present investigation was conducted to determine whether the cholesterol-raising properties of saturated fat and cholesterol-lowering properties of unsaturated fat are associated with levels of hepatic iron. The magnitude of hepatic iron retention was manipulated by feeding rats diets that were either copper-deficient or -adequate, iron-adequate or -supplemented, and contained either beef tallow or corn oil. Weanling male Sprague-Dawley rats were randomly divided into eight dietary groups according to the type of dietary fat (beef tallow or corn oil) and level of dietary copper (0.74 or 6.9 mu g Cu/g diet) or iron (44.4 or 86.7 mu g Fe/g diet). Beef tallow and copper deficiency alone increased hepatic iron levels, which in turn were associated with increased plasma cholesterol. When the three dietary factors were combined, ie, iron, beef tallow, and copper deficiency, they induced the highest magnitude of hepatic iron retention, which in turn was associated with the highest concentration of plasma cholesterol, In contrast, when hepatic iron retention was not increased, such as by feeding a diet containing corn oil or by consumption of a copper-adequate diet, plasma cholesterol was not elevated. Based on these data, it is suggested that nutrients that have the ability to increase hepatic iron have the potential to increase plasma cholesterol. Copyright (C) 1999 by W.B. Saunders Company.