Adaptive developmental plasticity: Compartmentalized responses to environmental cues and to corresponding internal signals provide phenotypic flexibility
Adaptive developmental plasticity: Compartmentalized responses to environmental cues and to corresponding internal signals provide phenotypic flexibility
复制标题
适应性发育可塑性：对环境线索和相应内部信号的划分反应提供了表型灵活性
作者：
A. R. Mateus;Manuel Marques;Vicencio Oostra;E. Lafuente;P. Brakefield;B. Zwaan;P. Beldade
背景发育的环境调节可以导致同一基因产生不同的表型，并为生物体提供应对环境异质性的手段。环境对发育结果的影响通常是由荷尔蒙信号调节的，荷尔蒙信号将有关外部线索的信息传递给发育中的组织。虽然这种可塑性是发育的一种广泛属性，但并不是所有发育中的组织都具有同样的可塑性。为了理解生物体如何将环境输入整合到连贯的成体表型中，我们必须知道不同的身体部位是如何独立或一致地对外部暗示和相应的内部信号做出反应的。结果我们在一个适应性发育可塑性的实验模型--蝴蝶Bcyclus anynana中量化了温度和蜕皮激素操作对生长后组织模式的影响。根据自然选择或性选择进化出的一系列特征，我们发现，同一组织内的不同细胞组对外部环境提示和内部激素信号的敏感性和反应模式令人惊讶地截然不同。除了那些推测与配偶选择有关的翅膀特征外，所有其他特征都对发育温度做出反应，其中，除了没有暴露在捕食者面前的翅膀特征之外，所有其他特征都对荷尔蒙操纵做出反应。另一方面，虽然对温度的显著反应模式与自主发育的翅膀上的特征相反，但对激素操纵的显著反应与具有不同颜色命运的相邻细胞组形成对比。我们还发现，这些反应的空间区划不能用激素受体蛋白的空间或时间区划来解释。结论我们的结果揭示了成体表型的不同方面整合成反映和影响进化变化的发育和功能单位。重要的是，我们的发现强调了环境和生理之间的相互作用在塑造身体不同部位发育方面的复杂性。
BackgroundThe environmental regulation of development can result in the production of distinct phenotypes from the same genotype and provide the means for organisms to cope with environmental heterogeneity. The effect of the environment on developmental outcomes is typically mediated by hormonal signals which convey information about external cues to the developing tissues. While such plasticity is a wide-spread property of development, not all developing tissues are equally plastic. To understand how organisms integrate environmental input into coherent adult phenotypes, we must know how different body parts respond, independently or in concert, to external cues and to the corresponding internal signals.ResultsWe quantified the effect of temperature and ecdysone hormone manipulations on post-growth tissue patterning in an experimental model of adaptive developmental plasticity, the butterfly Bicyclus anynana. Following a suite of traits evolving by natural or sexual selection, we found that different groups of cells within the same tissue have sensitivities and patterns of response that are surprisingly distinct for the external environmental cue and for the internal hormonal signal. All but those wing traits presumably involved in mate choice responded to developmental temperature and, of those, all but the wing traits not exposed to predators responded to hormone manipulations. On the other hand, while patterns of significant response to temperature contrasted traits on autonomously-developing wings, significant response to hormone manipulations contrasted neighboring groups of cells with distinct color fates. We also showed that the spatial compartmentalization of these responses cannot be explained by the spatial or temporal compartmentalization of the hormone receptor protein.ConclusionsOur results unravel the integration of different aspects of the adult phenotype into developmental and functional units which both reflect and impact evolutionary change. Importantly, our findings underscore the complexity of the interactions between environment and physiology in shaping the development of different body parts.
影响因子：
2.6
作者：
Ketterson, Ellen D.;Atwell, Jonathan W.;McGlothlin, Joel W.
通讯作者：
McGlothlin, Joel W.