Toll-Like Receptor 4 Signaling in the Trabecular Meshwork.
Toll-Like Receptor 4 Signaling in the Trabecular Meshwork.
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小梁网中的Toll样受体4信号转导。
DOI：
10.3389/fcell.2022.936115
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发表时间：
2022
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
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作者：
原发性开角型青光眼是世界范围内导致失明的主要原因之一。随着针对小梁网络(TM)发病机制的治疗方法有限，迫切需要确定潜在的新靶点。最近的研究发现Toll样受体4参与了Toll样受体4的表达，它是促进转化生长因子β2(β2)及其下游细胞外基质产生的信号通路。在这篇综述中，我们研究了TLR4信号在小梁网络中的作用，以及内源性TLR4激活物(损伤相关分子模式(DAMPS))、细胞外基质(ECM)之间的相互作用以及对眼压的影响
Primary open-angle glaucoma is one of the leading causes of blindness worldwide. With limited therapeutics targeting the pathogenesis at the trabecular meshwork (TM), there is a great need for identifying potential new targets. Recent evidence has implicated Toll-like receptor 4 (TLR4) and it is signaling pathway in augmenting the effects of transforming growth factor beta-2 (TGFβ2) and downstream extracellular matrix production. In this review, we examine the role of TLR4 signaling in the trabecular meshwork and the interplay between endogenous activators of TLR4 (damage-associated molecular patterns (DAMPs)), extracellular matrix (ECM), and the effect on intraocular pressure
影响因子：
25.7
作者：
Li Y;Chang M;Abar O;Garcia V;Rowland C;Catanese J;Ross D;Broder S;Shiffman M;Cheung R;Wright T;Friedman SL;Sninsky J
通讯作者：
Sninsky J