Palladium-catalyzed alkylation-hydride reduction sequence: synthesis of meta-substituted arenes.
Palladium-catalyzed alkylation-hydride reduction sequence: synthesis of meta-substituted arenes.
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DOI：
10.1021/ol051628n
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发表时间：
2005-08
期刊：
影响因子：
5.2
通讯作者：
T. Wilhelm;M. Lautens
中科院分区：
文献类型：
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作者：
T. Wilhelm;M. Lautens
报道了一种新的三组分钯催化的多米诺反应，该反应通过芳基碘和伯烷基卤得到间位取代芳烃。在芳基碘和烷基卤两者上容许各种官能团。此外，同位素标记的研究提供了深入了解这种卡特拉尼型反应的机制。[反应：见正文]
A new three-component, palladium-catalyzed domino reaction which gives access to meta-substituted arenes using aryl iodides and primary alkyl halides is reported. Various functional groups are tolerated on both the aryl iodide and alkyl halide. In addition, isotopic labeling studies provide insight into the mechanism of this Catellani-type reaction. [reaction: see text]