Metabolic regulation of systemic acquired resistance.
Metabolic regulation of systemic acquired resistance.
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DOI：
10.1016/j.pbi.2021.102050
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发表时间：
2021-05
影响因子：
9.5
通讯作者：
J. Zeier
中科院分区：
文献类型：
--
作者：
J. Zeier
植物通过微调免疫刺激小分子的生物合成和代谢失活来实现生长和防御之间的最佳平衡。最近的研究表明，三个共同的枢纽参与的协同调节系统获得性抗性（SAR）的防御激素N-羟基哌啶酸（NHP）和水杨酸（SA）。首先，一组共同的调节蛋白参与其生物合成。其次，NHP和SA被相同的糖基转移酶UGT 76 B1葡糖基化，从而一致失活。第三，NHP通过SA受体NPR 1赋予免疫力，以在转录水平上重新编程植物，并引发植物增强防御能力。SA和NHP代谢的概述，并讨论了它们对长距离信号在SAR的贡献。
Plants achieve an optimal balance between growth and defense by a fine-tuned biosynthesis and metabolic inactivation of immune-stimulating small molecules. Recent research illustrates that three common hubs are involved in the cooperative regulation of systemic acquired resistance (SAR) by the defense hormones N-hydroxypipecolic acid (NHP) and salicylic acid (SA). First, a common set of regulatory proteins is involved in their biosynthesis. Second, NHP and SA are glucosylated by the same glycosyltransferase, UGT76B1, and thereby inactivated in concert. And third, NHP confers immunity via the SA receptor NPR1 to reprogram plants at the level of transcription and primes plants for an enhanced defense capacity. An overview of SA and NHP metabolism is provided, and their contribution to long-distance signaling in SAR is discussed.