Long-range neural and gap junction protein-mediated cues control polarity during planarian regeneration
Long-range neural and gap junction protein-mediated cues control polarity during planarian regeneration
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DOI：
10.1016/j.ydbio.2009.12.012
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发表时间：
2010-03-01
影响因子：
2.7
通讯作者：
Levin, Michael
中科院分区：
文献类型：
--
作者：
Oviedo, Nestor J.;Morokuma, Junji;Levin, Michael
具有协调干细胞行为以诱导特定大规模结构再生的能力将在退行性疾病、急性损伤和衰老的治疗中产生深远的影响。因此，识别和学习操纵决定生物体整体形态发生程序中新组织命运的顺序步骤是至关重要的。我们确定了新的早期信号，介导的中枢神经系统和3个innexin蛋白，决定的命运和轴向极性的再生组织在涡虫。缝隙连接依赖性和神经信号的调节特异性地诱导后部和侧部伤口中的异位前部再生胚基。这些异位前胚基分化新的大脑，建立永久的主轴重新建立在随后的几轮的不受干扰的再生。这些数据揭示了强大的新的控制模式的形成，并提出了一个建设性的模型连接神经输入和极性决定在再生的早期阶段。(C)2009 Elsevier Inc. All rights reserved.
Having the ability to coordinate the behavior of stem cells to induce regeneration of specific large-scale structures would have far-reaching consequences in the treatment of degenerative diseases, acute injury, and aging. Thus, identifying and learning to manipulate the sequential steps that determine the fate of new tissue within the overall morphogenetic program of the organism is fundamental. We identified novel early signals, mediated by the central nervous system and 3 innexin proteins, which determine the fate and axial polarity of regenerated tissue in planarians. Modulation of gap junction-dependent and neural signals specifically induces ectopic anterior regeneration blastemas in posterior and lateral wounds. These ectopic anterior blastemas differentiate new brains that establish permanent primary axes re-established during subsequent rounds of unperturbed regeneration. These data reveal powerful novel controls of pattern formation and suggest a constructive model linking nervous inputs and polarity determination in early stages of regeneration. (C) 2009 Elsevier Inc. All rights reserved.