Assessing the global threat from Zika virus.
Assessing the global threat from Zika virus.
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DOI：
10.1126/science.aaf8160
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发表时间：
2016-08-12
期刊：
影响因子：
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通讯作者：
Rodriguez-Barraquer I
中科院分区：
文献类型：
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作者：
Lessler J;Chaisson LH;Kucirka LM;Bi Q;Grantz K;Salje H;Carcelen AC;Ott CT;Sheffield JS;Ferguson NM;Cummings DA;Metcalf CJ;Rodriguez-Barraquer I
寨卡病毒（ZIKV）感染于1947年首次发现，直到2015年，它仍然是一种鲜为人知的热带疾病，当时它与巴西小头畸形发病率显著增加的明显关联引起了全世界的警觉。关于决定ZIKV感染及其并发症对全球威胁程度的关键因素的信息有限。在这里，我们回顾了ZIKV感染的流行病学，自然史和公共卫生影响;这种知识的经验基础;以及需要填补的关键知识空白。
First discovered in 1947, Zika virus (ZIKV) infection remained a little known tropical disease until 2015, when its apparent association with a significant increase in the incidence of microcephaly in Brazil raised alarms worldwide. There is limited information on the key factors that determine the extent of the global threat from ZIKV infection and resulting complications. Here, we review what is known about the epidemiology, natural history and public health impact of ZIKV infection; the empirical basis for this knowledge; and the critical knowledge gaps that need to be filled.