Heterogeneity of Parkinson's disease in the early clinical stages using a data driven approach
Heterogeneity of Parkinson's disease in the early clinical stages using a data driven approach
复制标题
DOI：
10.1136/jnnp.2003.033530
复制
发表时间：
2005-03-01
影响因子：
11
通讯作者：
Barker, RA
中科院分区：
文献类型：
--
作者：
Lewis, SJG;Foltynie, T;Barker, RA
目的：为了探讨异质性的特发性帕金森氏病（PD）的数据驱动之间的一个队列的患者在早期临床阶段的疾病会议建立的criteria.Methods：数据的人口统计学，运动，情绪和认知措施收集连续患者在早期阶段的PD（Hoehn和Yahr I-III）参加一个专业的PD诊所。数据的统计聚类分析允许产生的患者亚组的存在explored.Results：分析揭示了四个主要亚组：（a）具有年轻疾病发作的患者;（B）患者的主导亚组;（c）具有显著水平的损伤和轻度抑郁的非震颤主导亚组;和（c）具有快速疾病进展但无损伤的亚组。本研究通过使用数据驱动定义早期PD的临床异质性来补充和扩展先前的研究。在这项研究中采用的方法对帕金森病患者的亚组有重要的意义，产生的假设，定义这种常见的条件和其病因病理学基础的异质性，从而其治疗。
Objective: To investigate the heterogeneity of idiopathic Parkinson's disease (PD) in a data driven among a cohort of patients in the early clinical stages of the disease meeting established criteria.Methods: Data on demographic, motor, mood, and cognitive measures were collected from consecutive patients in the early stages of PD (Hoehn and Yahr I-III) attending a specialist PD clinic. Statistical cluster analysis of the data allowed the existence of the patient subgroups generated to explored.Results: The analysis revealed four main subgroups: (a) patients with a younger disease onset; (b) a dominant subgroup of patients; (c) a non-tremor dominant subgroup with significant levels of - impairment and mild depression; and (c a subgroup with rapid disease progression but no impairment.Conclusions: This study complements and extends previous research by using a data driven define the clinical heterogeneity of early PD. The approach adopted in this study for the subgroups of patients within Parkinson's disease has important implications for generating hypotheses on defining the heterogeneity of this common condition and its aetiopathological basis thus its treatment.