Structure, function, and biology of SHIP proteins.
Structure, function, and biology of SHIP proteins.
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DOI：
10.1101/gad.14.5.505
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发表时间：
2000-03
影响因子：
10.5
通讯作者：
L. Rohrschneider;J. Fuller;I. Wolf;Yan Liu;D. Lucas
中科院分区：
文献类型：
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作者：
L. Rohrschneider;J. Fuller;I. Wolf;Yan Liu;D. Lucas
至少对一个生物科学家来说，生命中一个“简单”的好奇是，如何控制一个单细胞生长和发育成一个完整的有机体。部分答案包括生长因子受体及其各自的配体，它们将信号传递到细胞膜并进入细胞核进行转录读出。这些细胞内信号的分子性质决定了信号的类型、所涉及的途径、随后的调控相互作用以及最终的转录因子激活/抑制。造血细胞的发育一直是一个卓有成效的系统
One of the “simple” curiosities of life, at least for a biological scientist, is how the growth and development of a complete organism from a single cell is controlled. Part of the answer includes growth factor receptors and their respective ligands, which transduce signals across cell membranes and into the nucleus for transcriptional readout. The molecular nature of these intracellular signals determines the type of signals, the pathways involved, subsequent regulatory interactions, and eventual transcription factor activation/repression. Hematopoietic cell development has been a fruitful system for the