Bladder cancer risk and personal hair dye use
Bladder cancer risk and personal hair dye use
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DOI：
10.1002/ijc.11729
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发表时间：
2004-04-20
影响因子：
6.4
通讯作者：
Karagas, MR
中科院分区：
文献类型：
--
作者：
Andrew, AS;Schned, AR;Karagas, MR
几项队列和病例对照研究发现，职业性暴露于染发剂的美发师和理发师患膀胱癌的风险增加。然而，与个人使用染发剂相关的致癌风险仍然不确定，因为几项大型病例对照和队列研究没有发现个人使用染发剂与膀胱癌之间的关联。为了解决这个问题，作者使用了1994年至1998年在新罕布什尔州进行的病例对照研究中采访的459例膀胱癌病例和665例对照的数据。参与者接受了一个结构化的个人访谈，询问染发剂使用史和膀胱癌风险因素。非条件Logistic回归分析用于计算与染发剂使用相关的比值比，同时控制潜在的混杂因素。任何染发剂使用史与男性膀胱癌发病率呈负相关[调整后的比值比（OR）= 0.5; 95%置信区间（Cl）=0.3-0.8]，尽管风险降低对个别染料类型没有统计学意义。在女性中，使用永久（调整OR = 1.5; 95%CI = 0.8-2.7）和冲洗型染发剂（调整OR = 1.7; 95%CI = 0.8-3.6）与膀胱癌风险适度升高相关，但统计学精确度有限;未发现与使用半永久性染料相关（调整OR = 0.7; 95%CI = 0.3-1.4）。对于永久性染发剂的使用，首次使用时年龄较小，频率较高和首次使用后时间较长的优势比最明显;然而，这些因素的风险没有明显的趋势。鉴于染发剂使用的普遍性，需要进一步的研究来解决特定颜色和类型的染发剂的影响沿着个体易感性的可能作用。(C)2004 Wiley-Liss，Inc.
Several cohort and case-control studies have found an increased risk of bladder cancer among hairdressers and barbers who are occupationally exposed to hair dyes. However, the carcinogenic risk associated with personal use of hair dyes remains uncertain since several large case-control and cohort studies did not find an association between personal hair dye use and bladder cancer. To address this question, the authors used data collected on 459 bladder cancer cases and 665 controls who were interviewed as part of a case-control study conducted in New Hampshire between 1994 and 1998. Participants underwent a structured personal interview with regard to history of hair dye use and bladder cancer risk factors. Unconditional logistic regression analysis was used to compute odds ratios that were associated with hair dye use, while controlling for potential confounding factors. A history of any hair dye use was inversely associated with bladder cancer incidence in men [adjusted odds ratio (OR) = 0.5; 95% confidence interval (Cl)=0.3-0.8], although risk reductions were not statistically significant for individual dye types. In women, use of permanent (adjusted OR = 1.5; 95%CI = 0.8-2.7) and rinse-type hair dye (adjusted OR = 1.7; 95%CI = 0.8-3.6) were associated with a modestly elevated risk of bladder cancer but with limited statistical precision; no association was found with use of semi-permanent dyes (adjusted OR = 0.7; 95%CI = 0.3-1.4). For permanent hair dye use, odds ratios were most pronounced for younger age at first use, higher frequency and prolonged time since first use; however there were no clear trends in risk by these factors. In light of the prevalence of hair dye use, further studies are needed that address the effects of specific colors and types of hair dyes along with the possible role of individual susceptibility. (C) 2004 Wiley-Liss, Inc.