Thrapeatic effects of mosapride citrate and lansoprazole for prevention of aspiration pneumonia in patients receiving gastrostomy feeding
Thrapeatic effects of mosapride citrate and lansoprazole for prevention of aspiration pneumonia in patients receiving gastrostomy feeding
复制标题
枸橼酸莫沙必利和兰索拉唑预防胃造口喂养患者吸入性肺炎的治疗作用
DOI：
10.1007/s00535-012-0725-6
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Takatori K
中科院分区：
文献类型：
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作者：
Tanimura T;Adachi K;Furuta K;Ohara S;Morita T;Koshino K;Miki M;Kinoshita Y;Takatori K
背景吸入性肺炎是接受胃造口喂养患者的一个新问题。本研究旨在阐明枸橼酸莫沙必利联合兰索拉唑预防胃造口喂养患者吸入性肺炎的治疗效果。方法以119例需要胃造口喂养的吞咽困难患者为研究对象。他们被随机分配到对照组（不用药）、兰索拉唑（15毫克，1天）和莫沙必利（5毫克，3天）组。观察6个月期间患者发热天数（≥37.8°C）、呕吐天数、抗生素使用情况及肺炎发生情况。结果观察期内，莫沙必利组肺炎发生率显著低于对照组（7/38 vs. 16/40,p= 0.038）和兰索拉唑组（20/41,p= 0.005）。与其他组相比，莫沙必利组也显示出发烧和抗生素使用天数的显著减少。多因素分析显示，裂孔疝的存在是重要的危险因素，给予莫沙必利是肺炎的重要预防因素。结论莫沙必利对胃造口喂养患者肺炎的发生有预防作用。
BackgroundAspiration pneumonia is an emerging problem in patients receiving gastrostomy feeding. This study is designed to clarify the therapeutic effects of mosapride citrate and lansoprazole for prevention of aspiration pneumonia in patients receiving gastrostomy feeding.MethodsThe study subjects were 119 patients with dysphasia who required gastrostomy feeding. They were randomly assigned to the control (without medication), lansoprazole (15 mg, 1/day), and mosapride (5 mg, 3/day) groups. The number of days with fever (≥37.8 °C), vomiting, and antibiotics administration, as well as the occurrence of pneumonia were investigated during the 6-month observation period.ResultsThe incidence of pneumonia during the observation period was significantly lower in the mosapride group as compared to the control (7/38 vs. 16/40,p= 0.038) and lansoprazole (vs. 20/41,p= 0.005) groups. The mosapride group also showed a significant decrease in days with fever and antibiotics administration as compared to the other groups. Multivariate analysis revealed that the presence of hiatal hernia was a significant risk factor and administration of mosapride was a significant preventive factor for pneumonia.ConclusionMosapride has a preventive effect on occurrence of pneumonia in patients receiving gastrostomy feeding.