Direct and indirect actions of thyrotropin-releasing hormone on neonatal rat motoneurons in vitro.
Direct and indirect actions of thyrotropin-releasing hormone on neonatal rat motoneurons in vitro.
复制标题
促甲状腺激素释放激素对体外新生大鼠运动神经元的直接和间接作用。
DOI：
10.1016/0304-3940(90)90610-l
复制
发表时间：
1990
影响因子：
2.5
通讯作者：
Dun,NJ
中科院分区：
文献类型：
--
作者：
Wang,MY;Dun,NJ
In addition to causing a slow depolarization, thyrotropin-releasing hormone (TRH, 5–10 μM) evoked synaptic activity in antidromically identified motoneurons in thin transverse neonatal rat spinal cord slices. The synaptic activity but not the slow depolarization was reversibly abolished by TTX or low Ca2+/high Mg2+solution. Furthermore, the TRH-induced synaptic activity was eliminated by the glutamate receptor antagonist kynurenic acid (0.5 or 1 mM) and/or the glycine receptor antagonist strychnine (1 μM). Our results indicate that in addition to depolarizing motoneurons, TRH modifies the activity of spinal interneurons which may secondarily alter the activity of motoneurons.
