M-tuberculosis persistence, latency, and drug tolerance
M-tuberculosis persistence, latency, and drug tolerance
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DOI：
10.1016/j.tube.2003.08.003
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发表时间：
2004-01-01
期刊：
影响因子：
3.2
通讯作者：
McKinney, JD
中科院分区：
文献类型：
--
作者：
Gomez, JE;McKinney, JD
结核分枝杆菌作为病原体的成功很大程度上归因于其在宿主组织中持续存在的能力，其中在体外快速杀菌的药物需要长时间给药以实现可比的效果。潜伏期是未经治疗或治疗不完全的M的常见结果。结核病感染，造成未来疾病和传染病的长期储存库。虽然细菌与其宿主之间的相互作用导致慢性或潜伏性感染在很大程度上仍然是不确定的，近年来已经看到了在这一领域的兴趣和研究活动的复苏。在这里，我们回顾了一些经典的研究，导致我们目前的理解M。结核病的持久性，并讨论了不同的方法，现在正在采取承担这一重要问题。爱思唯尔有限公司出版
The success of Mycobacterium tuberculosis as a pathogen is largely attributable to its ability to persist in host tissues, where drugs that are rapidly bactericidal in vitro require prolonged administration to achieve comparable effects. Latency is a frequent outcome of untreated or incompletely treated M. tuberculosis infection, creating a long-standing reservoir of future disease and contagion. Although the interactions between the bacterium and its host that result in chronic or Latent infection are still largely undefined, recent years have seen a resurgence of interest and research activity in this area. Here we review some of the classic studies that have led to our current understanding of M. tuberculosis persistence, and discuss the varied approaches that are now being brought to bear on this important problem. Published by Elsevier Ltd.