EXPOSURE TO RESIDENTIAL ELECTRIC AND MAGNETIC-FIELDS AND RISK OF CHILDHOOD LEUKEMIA
EXPOSURE TO RESIDENTIAL ELECTRIC AND MAGNETIC-FIELDS AND RISK OF CHILDHOOD LEUKEMIA
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DOI：
10.1093/oxfordjournals.aje.a116176
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发表时间：
1991-11-01
影响因子：
5
通讯作者：
PETERS, JM
中科院分区：
文献类型：
--
作者：
LONDON, SJ;THOMAS, DC;PETERS, JM
在加州洛杉矶县，一项针对出生至10岁儿童的病例对照研究中，通过测量、布线配置和自我报告的器具使用情况评估了家中暴露于电场和磁场与白血病风险之间的关系。病例通过1980年至1987年基于人群的肿瘤登记处确定。对照组来自朋友，通过随机数字拨号。从232例病例和232名对照中获得了访谈。可供分析的是24小时或更长时间内儿童卧室的磁场测量值（164例和144例对照），磁场和电场的现场测量值（140例和109例对照）以及布线配置（219例和207例对照）。白血病风险与测量的磁场或电场之间没有明显的联系。观察到Denver Wertheimer-Leeper接线配置与儿童白血病风险之间的关联（极高相对于极低电流和地下配置的比值比= 2.15，95%置信区间1.08-4.28;趋势p = 0.008），并且通过调整潜在混杂因素未发生实质性改变。病例比对照组更有可能报告使用了几种产生高电场和磁场的电器。我们的研究结果支持儿童白血病风险与布线配置之间的关联，但不是电场和磁场的直接测量。
The relation between exposure to electric and magnetic fields in the home, as assessed by measurements, wiring configuration, and self-reported appliance use, and risk of leukemia was investigated in a case-control study among children from birth to age 10 years in Los Angeles County, California. Cases were ascertained through a population-based tumor registry from 1980 to 1987. Controls were drawn from friends and by random digit dialing. Interviews were obtained from 232 cases and 232 controls. Available for analysis were measurements of the magnetic field in the child's bedroom over 24 hours or longer (164 cases and 144 controls), spot measurements of magnetic and electric fields (140 cases and 109 controls), and wiring configuration (219 cases and 207 controls). No clear associations between leukemia risk and measured magnetic or electric fields were seen. An association between the Denver Wertheimer-Leeper wiring configuration and childhood leukemia risk was observed (odds ratio for very high relative to very low current and underground configuration combined = 2.15, 95% confidence interval 1.08-4.28; p for trend = 0.008) and was not substantially altered by adjustment for potential confounding factors. Cases were more likely than controls to report use of several appliances that produce high electric and magnetic fields. Our results support an association between childhood leukemia risk and wiring configuration, but not direct measurements of electric and magnetic fields.