Helicobacter pylori, transmission routes and recurrence of infection: state of the art.
Helicobacter pylori, transmission routes and recurrence of infection: state of the art.
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DOI：
10.23750/abm.v89i8-s.7947
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发表时间：
2018-12-17
期刊：
影响因子：
--
通讯作者：
De' Angelis, Gian Luigi
中科院分区：
文献类型：
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作者：
Kayali, Stefano;Manfredi, Marco;De' Angelis, Gian Luigi
幽门螺杆菌（H.幽门螺杆菌感染是人类最常见的感染之一，影响超过一半的人口。由于社会经济和卫生条件不同，农村发展中地区的感染率（超过80%）与城市发达地区（不到40%）相差很大。H.幽门螺杆菌感染通常在儿童时期获得;感染者通常无症状，但约30%的个体可能发展为轻度至重度上消化道疾病，如胃炎、消化性溃疡、胃癌或MALT淋巴瘤。传播途径尚不清楚;人与人之间的传播，特别是在同一家庭内的传播似乎很普遍，但环境污染也是可能的。在没有特定治疗方案的情况下根除是非常不可能的，有效根除治疗后的再感染率非常罕见。如果有家庭成员受影响，再感染率会增加。
Helicobacter pylori (H. pylori) infection is one of the most common infection in humans, affecting more than half of the population. The prevalence of the infection varies widely in rural developing areas (more than 80%) compared to urban developed ones (less than 40%), as a consequence of different socioeconomic and hygienic conditions. H. pylori infection is usually acquired during childhood; infected people usually remain asymptomatic, but about 30% of individuals may develop mild to severe upper gastrointestinal diseases such as gastritis, peptic ulcer, gastric cancer or MALT lymphoma. The transmission route is not clear yet; the person-to-person transmission, especially within the same family appears to be prevalent, but also environmental contamination is possible. The eradication without a specific therapeutic regimen is very unlikely and the reinfection rate after an effective eradication therapy is quite rare. The reinfection rate will increase if there are family members affected.