Increasing the Duration of Light Physical Activity Ameliorates Insulin Resistance Syndrome in Metabolically Healthy Obese Adults
Increasing the Duration of Light Physical Activity Ameliorates Insulin Resistance Syndrome in Metabolically Healthy Obese Adults
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DOI：
10.3390/cells9051189
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发表时间：
2020-05-01
期刊：
影响因子：
6
通讯作者：
Ahmad, Rasheed
中科院分区：
文献类型：
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作者：
Al-Rashed, Fatema;Alghaith, Abdulwahab;Ahmad, Rasheed
肥胖是胰岛素抵抗综合征（IRS）的一个众所周知的危险因素。然而，有限的数据是关于身体活动（PA）的强度对调节IRS的能力的影响。本研究旨在研究持续时间较长的轻度PA与单次急性中度或剧烈PA对改善IRS指标的有益影响。60名代谢健康肥胖（MHO）参与者，30名男性和30名女性，身体质量指数（BMI）>= 30被纳入本研究。使用加速度计测量PA水平，并使用流式细胞术分析单核细胞表面标志物的表达。采用酶联免疫吸附试验（ELISA）测定血浆细胞因子的分泌。单变量回归分析评价了活动描记术评估的PA指标、炎性细胞因子和胰岛素抵抗。PA的持续时间较长被认为与胰岛素抵抗（HOMA-IR）的稳态模型评估，较低的血脂水平，单核细胞的炎症细胞因子的表达。尽管发现较高强度的PA与较低的体脂百分比相关，但仅发现光强度PA是有益的，因为它与改善的胰岛素敏感性和较低的炎症标志物表达相关。总之，全天维持较长时间的低强度PA可能更有利于减少炎症和改善胰岛素抵抗。这项研究支持了一个更可行的方法模型，以获得有益的生活方式的改变，以预防代谢健康的成年肥胖症患者的IRS。
Obesity is a well-known risk factor for insulin resistance syndrome (IRS). Nevertheless, limited data are available regarding the effects of physical activity (PA) intensity on the ability to modulate IRS. The study aim was to investigate the beneficial effects of the longer duration of light PA vs. a single bout of the acute moderate or vigorous PA for improvement in IRS indicators. Sixty metabolically healthy obese (MHO) participants, 30 males and 30 females, with body mass index (BMI) of >= 30 were enrolled in this study. PA levels were measured using an accelerometer, and the expression of monocytic surface markers was analyzed using flow cytometry. Plasma cytokines' secretion was determined by enzyme-linked immunosorbent assay (ELISA). Univariate regression analysis evaluated the actigraphy-assessed PA measures, inflammatory cytokines, and insulin resistance. The longer duration of PA was found to be associated with the homeostatic model assessment of insulin resistance (HOMA-IR), a lower lipid profile, and the expression of inflammatory cytokines by monocytes. Even though, higher intensities of PA were found to be associated with lower body fat percentage, only the light intensity PA was found to be beneficial as it associated with the improved insulin sensitivity and lower expression of inflammatory markers. In conclusion, maintaining the longer duration of low-intensity PA throughout the day could be more beneficial for reducing inflammation and improving insulin resistance. This study supports a more feasible approach model to gain beneficial lifestyle changes for the prevention of IRS in metabolically healthy adults with obesity.