Factors associated with overall survival and relief of dysphagia in advanced esophageal cancer patients after 125I seed-loaded stent placement: a multicenter retrospective analysis
Factors associated with overall survival and relief of dysphagia in advanced esophageal cancer patients after 125I seed-loaded stent placement: a multicenter retrospective analysis
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晚期食管癌患者 I-125 粒子负载支架置入后总体生存率和吞咽困难缓解的相关因素：多中心回顾性分析
DOI：
10.1093/dote/doz012
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发表时间：
2019-12-01
影响因子：
2.6
通讯作者：
Teng, G-J
中科院分区：
文献类型：
--
作者：
Qin, J.;Zhu, H-D;Teng, G-J
碘125（I-125）种子支架的放置位置已成为中国恶性食管狭窄的有效抑制。我们进行了一项回顾性研究，以确定晚期食管癌患者中这种辐射支架位置的预后因素。从2012年6月至2016年3月，在中国的五家医院中，总共包括201个接受I-125种子的支架放置的患者。使用了针对分层因子调整的COX回归模型，并进行了逐步的多元分析，以根据预处理临床特征分别预测吞咽困难的总体生存和缓解。确定了三个独立的预后因素的总生存期：组织病理学亚型（鳞状细胞癌与腺癌，危险比[HR] 1.45，95％置信区间[CI95％]：1.01-2.09，P = 0.046），P = 0.046，> = 66 g/l vs. = 71年VS。
Iodine-125 (I-125) seed-loaded stent placement has served as an effective palliation for malignant esophageal strictures in China. We performed a retrospective study to identify the prognostic factors of this irradiation stent placement in advanced esophageal cancer patients. A total of 201 patients who underwent I-125 seed-loaded stent placement were included in this study from June 2012 to March 2016 at five hospitals in China. The Cox regression models adjusted for stratification factors were used, and a stepwise multivariate analysis was performed to predict the overall survival and relief of dysphagia on the basis of pretreatment clinical characteristics, respectively. Three independent prognostic factors were identified for overall survival: histopathological subtype (squamous cell carcinoma vs. adenocarcinoma, hazard ratio [HR] 1.45, 95% confidence interval [CI95%]: 1.01-2.09, P = 0.046), serum total protein (>= 66 g/L vs. = 71 years vs.