Early GABA(A) receptor clustering during the development of the rostral nucleus of the solitary tract.
Early GABA(A) receptor clustering during the development of the rostral nucleus of the solitary tract.
复制标题
孤束喙核发育过程中的早期 GABA(A) 受体聚集。
DOI：
10.1046/j.1469-7580.2003.00169.x
复制
发表时间：
2003
影响因子：
2.4
通讯作者：
Schweitzer,L
中科院分区：
文献类型：
--
作者：
Heck,WL;Basaraba,AM;Slusarczyk,A;Schweitzer,L
While there is an abundance of gamma‐aminobutyric acid (GABA) in the gustatory zone of the nucleus of the solitary tract of the perinatal rat, we know that GABAergic synapse formation is not complete until well after birth. Our recent results have shown that GABABreceptors are present at birth in the cells of the nucleus; however, they do not redistribute and cluster at synaptic sites until after PND10. The present study examined the time course of appearance and redistribution of GABAAreceptors in the nucleus. GABAAreceptors were also present at birth. However, in comparison to GABABreceptors, GABAAreceptors underwent an earlier translocation to synaptic sites. Extrasynaptic label, for example, of GABAAreceptors was non‐existent compared to GABABreceptors at PND10 and well‐defined clusters of GABAAreceptors could be seen as early as PND1. We propose that while GABAAreceptors may play an early neurotransmitter role at the synapse, GABABreceptors may play a non‐transmitter neurotrophic role.
