Inhibition of the development of hepatocellular carcinomas by phenyl N-tert-butyl nitrone in rats fed with a choline-deficient, L-amino acid-defined diet.
Inhibition of the development of hepatocellular carcinomas by phenyl N-tert-butyl nitrone in rats fed with a choline-deficient, L-amino acid-defined diet.
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DOI：
10.1016/j.canlet.2003.10.003
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发表时间：
2004-03
期刊：
影响因子：
9.7
通讯作者：
D. Nakae;Fumiyuki Uematsu;H. Kishida;O. Kusuoka;Shin-Ichi Katsuda;Midori Yoshida;Masakazu Takahashi;A. Maekawa;A. Denda;Y. Konishi;Y. Kotake;R. Floyd
中科院分区：
文献类型：
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作者：
D. Nakae;Fumiyuki Uematsu;H. Kishida;O. Kusuoka;Shin-Ichi Katsuda;Midori Yoshida;Masakazu Takahashi;A. Maekawa;A. Denda;Y. Konishi;Y. Kotake;R. Floyd
本文观察了自旋捕捉剂苯基N-叔丁基硝酮（PBN）对以胆碱缺乏、l-氨基酸限定（CDAA）饲料喂养的雄性Wistar大鼠70周的恶性肿瘤发生的影响。PBN（饮用水中0.065%）在所有70周或仅在前26周给药时降低了肝细胞腺瘤和癌的发生率、多样性和可能的大小，在仅在最后44周给药时降低了癌的发生率、多样性和可能的大小，但没有腺瘤。这些结果表明，PBN可以预防CDAA饮食模型中坦率HCC的发展。PBN的抗癌作用可能归因于防止HCA的发展及其向HCC的恶性转化。如果这些发现可以推广，PBN可能能够作为一个很好的工具，调查致癌过程的分子机制。
Effects of phenyl N-tert-butyl nitrone (PBN), a spin-trapping agent, on the development of frank cancers were examined in male Wistar rats fed with a choline-deficient, l-amino acid-defined (CDAA) diet for 70 weeks. PBN (0.065% in the drinking water) reduced incidences, multiplicities and possibly sizes of both hepatocellular adenomas and carcinomas when administered for all 70 weeks or only for the first 26 weeks, and those of carcinomas but not adenomas, when administered only for the last 44 weeks. These results indicate that PBN can prevent the development of frank HCCs in the CDAA diet model. The anti-carcinogenic effect of PBN may be ascribed to the prevention of both the development of HCAs and their malignant conversion to HCCs. If such findings can be generalized, PBN may be able to serve as a good tool to investigate molecular mechanisms underlying carcinogenic processes.