High affinity inhibitors of the dopamine transporter (DAT): novel biotinylated ligands for conjugation to quantum dots.
High affinity inhibitors of the dopamine transporter (DAT): novel biotinylated ligands for conjugation to quantum dots.
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DOI：
10.1016/j.bmcl.2006.05.097
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发表时间：
2006-09
影响因子：
2.7
通讯作者：
I. Tomlinson;J. N. Mason;R. Blakely;S. Rosenthal
中科院分区：
文献类型：
--
作者：
I. Tomlinson;J. N. Mason;R. Blakely;S. Rosenthal
能够抑制多巴胺转运蛋白（DAT）的化合物可与硒化镉/硫化锌/核壳纳米晶体结合，可用于成像DAT在神经元细胞膜中的位置和分布。这封信描述了DAT拮抗剂GBR 12909和GBR 12935的生物素化类似物的合成，可以附着在链亲和素包被的硒化镉/硫化锌/核壳纳米晶体上。
Compounds capable of inhibiting the dopamine transporter protein (DAT) that can be conjugated to cadmium selenide/zinc sulfide/core shell nanocrystals may be used to image the location and distribution of the DAT in neuronal cell membranes. This letter describes the synthesis of biotinylated analogs of the DAT antagonists GBR 12909 and GBR 12935 that can be attached to streptavidin coated cadmium selenide/zinc sulfide/core shell nanocrystals.