Increased Th22 cells are independently associated with Th17 cells in type 1 diabetes
Increased Th22 cells are independently associated with Th17 cells in type 1 diabetes
复制标题
1 型糖尿病中 Th22 细胞增加与 Th17 细胞独立相关
DOI：
10.1007/s12020-013-0030-z
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发表时间：
2014-05-01
期刊：
影响因子：
3.7
通讯作者：
Yang, Tao
中科院分区：
文献类型：
--
作者：
Xu, Xinyu;Zheng, Shuai;Yang, Tao
Type 1 diabetes (T1D) is perceived as an autoimmune disease caused by T cell-mediated destruction of the insulin-producing pancreatic beta cells. However, the number of inflammatory T cells in blood, as well as the relative importance of each cell type is unclear. Forty-two patients with T1D and 30 controls were enrolled. Circulating primary CD4(+) or CD8(+) T cells were quantified with 5-color flow cytometry. Serum IL-22 and IL-17 levels were examined by ELISA. Serum autoantibodies were measured by radio-binding assays, using S-35-labeled glutamic acid decarboxylase-65 (GAD65), protein tyrosine phosphatase-2 (IA-2), and zinc transporter 8 (ZnT8). Th17-Th22 and Tc1-Tc17 were significantly elevated in patients with T1D compared to control subjects, while there were no significant differences in Th1 cells. The levels of these T cells in different stages of T1D were investigated. Th22 cells showed a positive correlation with Th17 cells in T1D patients. However, we did not find any correlation between IL-17 and IL-22 in sera. Autoantibodies were not significantly different between patients with early T1D and those who have had it for a longer duration. This study indicates that Th22 may contribute to the pathogenesis of T1D. Blockade of Th22 cells might be of clinical profit in T1D patients.
