Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis
Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis
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DOI：
10.1016/j.jbspin.2007.06.016
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发表时间：
2008-05-01
期刊：
影响因子：
4.2
通讯作者：
Calguneri, Meral
中科院分区：
文献类型：
--
作者：
Kisacik, Bunyamin;Tufan, Abdurrahman;Calguneri, Meral
目的：本研究的目的是探讨MPV与类风湿关节炎和强直性脊柱炎临床疾病活动指数的相关性（男性/女性：7/25，平均年龄：49 ± 13）和30例活动性AS患者（男性/女性：151 +/- 15，平均年龄：36 +/- 12）沿着26例骨关节炎（OA）患者（男性/女性：4/22，平均年龄：52 ± 8）和29名年龄匹配的健康受试者（男/女：5/24，平均年龄：41 +/- 7）分别作为RA和AS的对照组。与对照组相比，AS患者和患有活动性疾病的RA患者的MPV均显著较低（RA vs OA p < 0.001，AS vs健康受试者p < 0.001）。治疗后，AS和RA的MPV值显著增加（P < 0.001）。然而，RA患者的MPV值仍略低于OA患者（p = 0.019）。治疗2个月后，AS患者的MPV值与BASDAI评分呈负相关（r = -0.507; p = 0.004）。结论：我们的研究结果表明，评估MPV可能提供更多的信息，炎症在AS和RA。(C)2008年，Elsevier Masson SAS。All rights reserved.
Aims: The aim of this retrospective study was to investigate the correlation between MPV and the clinical disease activity indices of rheumatoid arthritis and ankylosing spondylitis.Methods: The study consisted of 32 active RA patients (males/females: 7/25, mean age: 49 +/- 13) and 30 active AS patients (males/females: 151 +/- 15, mean age: 36 +/- 12) along with 26 osteoarthritis (OA) patients (males/females: 4/22, mean age: 52 +/- 8) and 29 age-matched healthy subjects (males/females: 5/24, mean age: 41 +/- 7) as control groups for RA and AS, respectively.Results: MPV was significantly lower in both AS patients and RA patients with active disease as compared to controls (RA vs OA p < 0.001, AS vs healthy subjects p < 0.001). After treatment MPV values significantly increased in AS and RA (p < 0.001 for all). However, MPV values remained somewhat lower in RA patients than OA patients (p = 0.019). There was a negative correlation between MPV values and BASDAI scores in AS patients after two months of treatment (r = -0.507; p = 0.004).Conclusion: Our results suggest that assessment of MPV may provide additional information about inflammation in AS and RA. (C) 2008 Elsevier Masson SAS. All rights reserved.