Uncertainty About Mapping Future Actions Into Rewards May Underlie Performance on Multiple Measures of Impulsivity in Behavioral Addiction: Evidence From Parkinson's Disease
Uncertainty About Mapping Future Actions Into Rewards May Underlie Performance on Multiple Measures of Impulsivity in Behavioral Addiction: Evidence From Parkinson's Disease
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DOI：
10.1037/a0032079
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发表时间：
2013-04-01
影响因子：
1.9
通讯作者：
Roiser, Jonathan P.
中科院分区：
文献类型：
--
作者：
Averbeck, Bruno B.;Djamshidian, Atbin;Roiser, Jonathan P.
帕金森病（PD）患者的一个子集发展行为成瘾，这可能是由于他们的多巴胺替代疗法。最近，几个研究小组已经比较了有和没有行为成瘾的PD患者在被认为是衡量冲动性方面的任务。这些实验中的一些，包括信息采样，对新的刺激和时间折扣的偏见，已经显示出与没有行为成瘾的PD患者之间的差异。我们已经开发了一个统一的理论框架，使我们能够在所有这三个任务中建模行为。通过用一个单一的框架来探索患者群体在这三个任务上的表现，我们可以提出关于所有三个任务背后的共同机制的问题。我们的研究结果表明，在所有三个任务中看到的效果可以解释为不确定性的能力映射到奖励未来的行动。更具体地说，建模是一致的假设，即行为成瘾的群体的行为，如果他们不能使用实验背景下提供的信息，以改善未来的奖励引导的行动。未来的研究将有必要更坚定地建立（或反驳）这一假设。我们讨论了这个结果的光是什么是已知的病理基础的PD患者的行为成瘾。
A subset of patients with Parkinson's disease (PD) develops behavioral addictions, which may be due to their dopamine replacement therapy. Recently, several groups have been comparing PD patients with and without behavioral addictions on tasks that are thought to measure aspects of impulsivity. Several of these experiments, including information sampling, a bias toward novel stimuli and temporal discounting, have shown differences between PD patients with and without behavioral addictions. We have developed a unifying theoretical framework that allows us to model behavior in all three of these tasks. By exploring the performance of the patient groups on the three tasks with a single framework, we can ask questions about common mechanisms that underlie all three. Our results suggest that the effects seen in all three tasks can be accounted for by uncertainty about the ability to map future actions into rewards. More specifically, the modeling is consistent with the hypothesis that the group with behavioral addictions behaves as if they cannot use information provided within the experimental context to improve future reward guided actions. Future studies will be necessary to more firmly establish (or refute) this hypothesis. We discuss this result in light of what is known about the pathology that underlies the behavioral addictions in the PD patients.