Hippocampal spatial representations require vestibular input
Hippocampal spatial representations require vestibular input
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DOI：
10.1002/hipo.1112
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发表时间：
2002-01-01
期刊：
影响因子：
3.5
通讯作者：
Taube, JS
中科院分区：
文献类型：
--
作者：
Stackman, RW;Clark, AS;Taube, JS
海马体的形成对于形成多种刺激之间关系的陈述性表征至关重要。啮齿类动物的海马体形成，包括内嗅皮层和丘下复合体，对空间记忆至关重要。两类海马神经元与空间特征相关。位置细胞集体绘制空间位置，只有当动物占据了该细胞的“位置场”，即更大环境的一个特定子区域时，每个细胞才会放电。头部方向（HD）细胞编码定向方向，当大鼠的头部朝向特定的“首选发射方向”时，每个HD细胞都会发射信号。地标和内部信号（如前庭、运动干扰复制）都影响位置和HD细胞活动。然而，就像导航一样，地标被认为对位置和HD细胞活动有更大的影响。本研究表明，前庭系统的暂时失活导致海马位置细胞的位置特异性放电和丘下后HD细胞的方向特异性放电中断，但不改变运动功能。位置和HD细胞的活动在一段时间内恢复，与前庭功能的恢复相似。这些结果表明，前庭信号对海马空间表征的表达有重要影响，并可能解释前庭功能障碍患者的导航缺陷。
The hippocampal formation is essential for forming declarative representations of the relationships among multiple stimuli. The rodent hippocampal formation, including the entorhinal cortex and subicular complex, is critical for spatial memory. Two classes of hippocampal neurons fire in relation to spatial features. Place cells collectively map spatial locations, with each cell firing only when the animal occupies that cell's "place field," a particular subregion of the larger environment. Head direction (HD) cells encode directional heading, with each HD cell firing when the rat's head is oriented in that cell's particular "preferred firing direction." Both landmarks and internal cues (e.g., vestibular, motor efference copy) influence place and HD cell activity. However, as is the case for navigation, landmarks are believed to exert greater influence over place and HD cell activity. Here we show that temporary inactivation of the vestibular system led to the disruption of location-specific firing in hippocampal place cells and direction-specific discharge of postsubicular HD cells, without altering motor function. Place and HD cell activity recovered over a time course similar to that of the restoration of vestibular function. These results indicate that vestibular signals provide an important influence over the expression of hippocampal spatial representations, and may explain the navigational deficits of humans with vestibular dysfunction.