Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0): Recommendations for Standardized FDG-PET/CT Experiments in Humans.
Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0): Recommendations for Standardized FDG-PET/CT Experiments in Humans.
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DOI：
10.1016/j.cmet.2016.07.014
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发表时间：
2016-08-09
期刊：
影响因子：
29
通讯作者：
Wahl RL
中科院分区：
文献类型：
--
作者：
Chen KY;Cypess AM;Laughlin MR;Haft CR;Hu HH;Bredella MA;Enerbäck S;Kinahan PE;Lichtenbelt Wv;Lin FI;Sunderland JJ;Virtanen KA;Wahl RL
人体棕色脂肪组织(BAT)的存在、代谢活动和估计质量通常是通过使用正电子发射断层扫描和X射线计算机断层扫描(FDG-PET/CT)来测量的，方法是在预计包含BAT的人体区域，通过冷暴露对[18F]氟脱氧葡萄糖(FDG)的摄取进行成像。描述人类蝙蝠的流行病学和生物学的努力受到各种实验做法的阻碍，这使得很难在不同的实验室之间直接比较结果。2014年11月4日，国家糖尿病、消化和肾脏疾病研究所组建了一个专家小组，讨论对人蝙蝠进行FDG-PET/CT实验、数据分析和结果发布的最低要求。这导致了影像研究中的棕色脂肪报告标准(BARCIST 1.0)。由于目前还没有完全经过验证的最佳实践，专家小组的建议旨在增强实验之间的可比性，而不是限制实验设计或可以提出的问题。
Human brown adipose tissue (BAT) presence, metabolic activity and estimated mass are typically measured by imaging [18F]fluorodeoxyglucose (FDG) uptake in response to cold exposure in regions of the body expected to contain BAT, using positron emission tomography combined with x-ray computed tomography (FDG-PET/CT). Efforts to describe the epidemiology and biology of human BAT are hampered by diverse experimental practices, making it difficult to directly compare results among laboratories. An expert panel was assembled by the National Institute of Diabetes and Digestive and Kidney Diseases on November 4, 2014 to discuss minimal requirements for conducting FDG-PET/CT experiments of human BAT, data analysis, and publication of results. This resulted in Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0). Since there are no fully-validated best practices at this time, panel recommendations are meant to enhance comparability across experiments, but not to constrain experimental design or the questions that can be asked.