Decrease of Circulating Insulin Antibodies in Two Patients Treated with Continuous Subcutaneous Infusion of Human Insulin (recombinant DNA)
Decrease of Circulating Insulin Antibodies in Two Patients Treated with Continuous Subcutaneous Infusion of Human Insulin (recombinant DNA)
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连续皮下输注人胰岛素（重组 DNA）治疗的两名患者循环胰岛素抗体下降
作者：
A. Spijker;J. Poortman;J. Thijssen;D. Erkelens
对2例持续皮下注射人胰岛素（重组DNA）的患者进行循环胰岛素抗体（CIA）检测。经血清预处理去除结合胰岛素和游离胰岛素后，用动力学平衡法测定CIA。我们观察到，将纯化的牛胰岛素或纯化的猪胰岛素改为CSII给药的人胰岛素，在3周后可检测到CIA逐渐下降，并且在改变后3个月后更为明显。这些发现表明，人胰岛素与CSII改善的代谢控制相结合，可显著减少IDDM患者的抗体形成。
Circulating insulin antibodies (CIA) were measured in two patients treated with continuous subcutaneous infusion (CSII) of human insulin (recombinant DNA). CIA were determined by a kinetic equilibrium assay after pretreatment of the serum to remove bound and free insulin. We observed that by changing from either purified bovine or purified porcine insulin to human insulin given by CSII, there is a gradual decrease in CIA detectable after 3 wk and more pronounced 3 mo after changing. These findings suggest that human insulin in combination with the improved metabolic control by CSII considerably reduces the antibody formation in patients with IDDM.