A cross-sectional study of exercise performance during the first 2 decades of life after the Fontan operation
A cross-sectional study of exercise performance during the first 2 decades of life after the Fontan operation
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DOI：
10.1016/j.jacc.2008.02.081
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发表时间：
2008-07-08
影响因子：
24
通讯作者：
Rhodes, Jonathan
中科院分区：
文献类型：
--
作者：
Paridon, Stephen M.;Mitchell, Paul D.;Rhodes, Jonathan
目的-本研究的目的是描述运动性能在第一个20年的生活中Fontan幸存者的横断面研究，并确定因素，影响运动performance.Background后Fontan程序的性能相对于健康受试者的性能降低。青春期前的数据是有限的，在不同年龄的运动性能的模式是unexplored.Methods坡道踏车进行呼气。数据进行了分析，为整个研究人群和亚群，没有达到最大的有氧能力。结果411名受试者测试（12.4 +/- 3.2岁），166达到最大的有氧能力。整个人群的峰值耗氧量（VO 2）为26.3 ml/kg/min（年龄和性别预测值的65%[预测值%]），次最大容量亚组低于最大容量亚组（分别为63%预测值和67%预测值; p = 0.02）。与峰值VO 2相比，在排除性无氧阈值（VAT）下的耗氧量保持得更好（总人群的预测值为78%）。运动峰值时较高的%预测O-2脉搏与较高的%预测峰值VO 2、工作率和VAT相关。青少年和男性与%预测峰值VO 2降低相关。超声心动图指标的心室功能和运动function.Conclusions之间的关系是令人惊讶的弱，Fontan患者的最大有氧能力降低与健康人相比，更好地保存次最大性能。与健康受试者相比，较高的O-2脉搏与较好的运动表现相关，而青春期和男性性别与运动表现下降相关。
Objectives The aim of this study was to describe exercise performance during the first 2 decades of life in Fontan survivors by a cross-sectional study and to identify factors that influence exercise performance.Background Exercise performance after the Fontan procedure is reduced relative to performance in healthy subjects. Data on pre-adolescents are limited, and the patterns of exercise performance in different ages are unexplored.Methods Ramp cycle ergometry was performed with expired gas. Data were analyzed for the entire study population and for subpopulations that did and did not achieve a maximal aerobic capacity.Results Of 411 subjects tested (12.4 +/- 3.2 years of age), 166 achieved a maximal aerobic capacity. Peak oxygen consumption (VO2) was 26.3 ml/kg/min (65% of predicted for age and gender [% predicted]) for the entire population and was lower in the submaximal capacity subgroup compared with the maximal capacity subgroup (63% predicted and 67% predicted, respectively; p = 0.02). Oxygen consumption at ventilatory anaerobic threshold (VAT) was better preserved (78% predicted for the total population) than peak VO2. Higher % predicted O-2 pulse at peak exercise was associated with greater % predicted peak VO2, work rate, and VAT. Adolescence and male gender were associated with decreased % predicted peak VO2. The relationship between echocardiographic indexes of ventricular function and exercise function was surprisingly weak.Conclusions In Fontan patients, maximal aerobic capacity is reduced compared with healthy subjects, with better preservation of submaximal performance. Higher O-2 pulse is associated with better exercise performance, whereas adolescence and male gender are associated with decreased performance compared with healthy subjects.