Cytogenetic "rogue" cells: what is their frequency, origin, and evolutionary significance?
Cytogenetic "rogue" cells: what is their frequency, origin, and evolutionary significance?
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细胞遗传学“流氓”细胞：它们的频率、起源和进化意义是什么？
DOI：
10.1073/pnas.83.4.1021
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发表时间：
1986
影响因子：
11.1
通讯作者：
J. Neel
中科院分区：
文献类型：
--
作者：
A. Awa;J. Neel
在从来自日本广岛的9818名年龄为9至37岁的个体获得的102，170个培养的淋巴细胞中，发现了24个表现出极端程度损伤的细胞。损伤包括多个双着丝粒染色体，甚至三着丝粒染色体，以及大量的片段，许多具有“双微体”的外观。“这些细胞的出现与父母暴露于原子弹，年龄，性别，年份或季节无关。它们是按个体非随机分布的。这种细胞最初在南美洲印第安人中被描述，也在美国和英国的居民中被记录;这似乎是一个世界性的现象。它们的原因仍然未知，也不知道它们是否发生在其他体细胞和生殖细胞中。如果是后者的情况下，这些细胞中受损最少的细胞偶尔成功地完成有丝分裂和减数分裂，这些细胞在肿瘤发生和演变的可能作用必须加以考虑。
Among 102,170 cultured lymphocytes obtained from 9818 individuals from Hiroshima, Japan, aged 9 to 37 years and scored for chromosomal abnormalities, 24 cells that exhibited an extreme degree of damage were encountered. The damage consists of multiple dicentric and even tricentric chromosomes, as well as numerous fragments, many with the appearance of "double minutes." The occurrence of these cells was not correlated with parental exposure to the atomic bomb, age, sex, year, or season. They were nonrandomly distributed by individual. Such cells were originally described in South American Indians and have also been recorded in inhabitants of the United States and the United Kingdom; this appears to be a world-wide phenomenon. Their cause remains unknown, and it is not known whether they occur in other somatic and germ-line cells. Should the latter be the case and should the least damaged of these cells occasionally successfully complete mitosis and meiosis, the possible role of such cells in oncogenesis and evolution must be considered.