Endurance and resistance exercise training programs elicit specific effects on sciatic nerve regeneration after experimental traumatic lesion in rats
Endurance and resistance exercise training programs elicit specific effects on sciatic nerve regeneration after experimental traumatic lesion in rats
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DOI：
10.1177/1545968307313502
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发表时间：
2008-07-01
影响因子：
4.2
通讯作者：
Achaval, Matilde
中科院分区：
文献类型：
--
作者：
Ilha, Jocemar;Araujo, Rafaela T.;Achaval, Matilde
Objective.观察耐力训练、抗阻训练以及耐力训练与抗阻训练相结合对大鼠坐骨神经损伤后后肢运动功能恢复和神经再生的影响。方法.对成年雄性大鼠进行坐骨神经挤压，神经损伤2周后，动物接受耐力、阻力和耐力-阻力组合训练计划5周。在训练期间，每周使用坐骨神经功能指数（SFI）监测功能恢复，并使用组织学和形态学神经分析来评估训练结束时的神经再生。结果抗阻训练组的SFI值从训练后第1周开始达到对照值，并在训练后第1、2、3周显著优于抗阻训练组，在训练后第1周显著优于同步训练组。在再生坐骨神经的远端部分，阻力训练组表现出更大程度的有髓纤维成熟比久坐，阻力训练，并同时训练组。此外，与久坐组相比，久坐训练组的神经内膜结缔组织面积百分比较小，有髓纤维面积百分比较大。结论这些数据提供的证据表明，耐力训练可以改善实验性创伤性损伤后的坐骨神经再生，阻力训练或2种策略的组合可能会延迟功能恢复，而不会改变坐骨神经纤维的再生。
Objective. To evaluate the effects of endurance, resistance, and a combination of both types of exercise training on hindlimb motor function recovery and nerve regeneration after experimental sciatic nerve lesion in rats. Methods. Sciatic nerve crush was performed on adult male rats, and after 2 weeks of the nerve lesion, the animals were submitted to endurance, resistance, and a combination of endurance-resistance training programs for 5 weeks. Over the training period, functional recovery was monitored weekly using the Sciatic Functional Index (SFI) and histological and morphometric nerve analyses were used to assess the nerve regeneration at the end of the trainings. Results. The SFI values of the endurance-trained group reached the control values from the first posttraining week and were significantly better than both the resistance-trained group at the first, second, and third posttraining weeks and the concurrent training group at the first posttraining week. At the distal portion of the regenerating sciatic nerve, the endurance-trained group showed a greater degree of the myelinated fiber maturation than the sedentary, resistance-trained, and concurrent training groups. Furthermore, the endurance-trained group showed a smaller percentage area of endoneurial connective tissue and a greater percentage area of myelinated fibers than the sedentary group. Conclusion. These data provide evidence that endurance training improves sciatic nerve regeneration after an experimental traumatic injury and that resistance training or the combination of 2 strategies may delay functional recovery and do not alter sciatic nerve fiber regeneration.