Expression of Sox4 and Sox11 is regulated by multiple mechanisms during retinal development
Expression of Sox4 and Sox11 is regulated by multiple mechanisms during retinal development
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DOI：
10.1016/j.febslet.2012.12.017
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发表时间：
2013-02
期刊：
影响因子：
3.5
通讯作者：
Ayumi Usui;Toshiro Iwagawa;Yujin Mochizuki;Atsumi Iida;M. Wegner;A. Murakami;Sumiko Watanabe
中科院分区：
文献类型：
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作者：
Ayumi Usui;Toshiro Iwagawa;Yujin Mochizuki;Atsumi Iida;M. Wegner;A. Murakami;Sumiko Watanabe
Sox 11和Sox 4在视网膜发育中起着关键作用，在此期间它们显示出特异性和独特的表达模式。Sox 11和Sox 4的表达是时间顺序的，尽管在某些视网膜亚型中空间重叠。功能获得和功能丧失分析表明，Notch信号抑制Sox 4在早期发育的视网膜中的表达，但在发育后期不抑制。组蛋白H3-乙酰化和H3-赖氨酸4三甲基化的水平在Sox 11基因座下降，在发展过程中，Sox 11的水平。Sox 4也有类似但不太明显的变化。对于这两个基因，组蛋白H3-赖氨酸27甲基化在发育过程中是低的，并在成人中显着增加。
Sox11 and Sox4 play critical roles in retinal development, during which they display specific and unique expression patterns. The expression of Sox11 and Sox4 is temporally sequential, albeit spatially overlapping in some retinal subtypes. Gain-of-function and loss-of-function analyses suggested that Notch signaling suppresses Sox4 expression in the early developing retina but not during the later period of development. The levels of histone H3-acetylation and H3-lysine 4 tri-methylation at the Sox11 locus declined during development, as did the levels of Sox11. A similar but less marked change was seen for Sox4. For both genes, histone H3-lysine 27 methylation was low during development and increased markedly in the adult.