Hair cortisol levels as a retrospective marker of hypothalamic-pituitary axis activity throughout pregnancy: Comparison to salivary cortisol
Hair cortisol levels as a retrospective marker of hypothalamic-pituitary axis activity throughout pregnancy: Comparison to salivary cortisol
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DOI：
10.1016/j.physbeh.2011.02.041
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发表时间：
2011-08-03
影响因子：
2.9
通讯作者：
Laudenslager, Mark L.
中科院分区：
文献类型：
--
作者：
D'Anna-Hernandez, Kimberly L.;Ross, Randal G.;Laudenslager, Mark L.
怀孕期间的母亲压力与负面的母婴结果有关。母体应激反应的一个潜在生物标志物是皮质醇，它是下丘脑-垂体-肾上腺轴活动的产物。这项研究评估了整个怀孕期间头发中的皮质醇水平，作为总皮质醇释放的标志。头发中的皮质醇水平已被证明是容易量化的，并且可以代表比单一唾液或血清测量更多的总皮质醇释放。头发皮质醇提供了一种简单的方法来监测总皮质醇释放在一段较长的时间。头发皮质醇水平测定从每个三个月（15，26和36周妊娠）和产后3个月。将头发皮质醇水平与14岁时3天内（3次/天）收集的昼夜唾液皮质醇水平进行比较。21例孕妇，孕龄18、23、29和34周，产后6周。正如预期的那样，唾液和头发的皮质醇水平在怀孕期间都会上升。头发皮质醇和昼夜唾液皮质醇曲线下面积相对于地面（AUCg）也相关整个怀孕。头发中的皮质醇水平是测量长期皮质醇活动的有效和有用的工具。头发皮质醇避免了与收集其他皮质醇测量（如血浆，尿液或唾液）相关的方法学问题，并且是整个妊娠期间HPA活性的可靠指标，反映了长时间内皮质醇的总释放。(C)2011 Elsevier Inc. All rights reserved.
Maternal stress during pregnancy is associated with negative maternal/child outcomes. One potential biomarker of the maternal stress response is cortisol, a product of activity of the hypothalamic-pituitaryadrenal axis. This study evaluated cortisol levels in hair throughout pregnancy as a marker of total cortisol release. Cortisol levels in hair have been shown to be easily quantifiable and may be representative of total cortisol release more than single saliva or serum measures. Hair cortisol provides a simple way to monitor total cortisol release over an extended period of time. Hair cortisol levels were determined from each trimester (15, 26 and 36 weeks gestation) and 3 months postpartum. Hair cortisol levels were compared to diurnal salivary cortisol collected over 3 days (3 times/day) at 14. 18, 23, 29, and 34 weeks gestational age and 6 weeks postpartum from 21 pregnant women. Both salivary and hair cortisol levels rose during pregnancy as expected. Hair cortisol and diurnal salivary cortisol area under the curve with respect to ground (AUCg) were also correlated throughout pregnancy. Levels of cortisol in hair are a valid and useful tool to measure long-term cortisol activity. Hair cortisol avoids methodological problems associated with collection other cortisol measures such as plasma, urine, or saliva and is a reliable metric of HPA activity throughout pregnancy reflecting total cortisol release over an extended period. (C) 2011 Elsevier Inc. All rights reserved.