HISTAMINE DIRECTLY GATES A CHLORIDE CHANNEL IN LOBSTER OLFACTORY RECEPTOR NEURONS
HISTAMINE DIRECTLY GATES A CHLORIDE CHANNEL IN LOBSTER OLFACTORY RECEPTOR NEURONS
复制标题
DOI：
10.1073/pnas.86.20.8137
复制
发表时间：
1989-10-01
影响因子：
11.1
通讯作者：
ACHE, BW
中科院分区：
文献类型：
--
作者：
MCCLINTOCK, TS;ACHE, BW
生物胺介导多细胞生物体中细胞间通讯的类型。迄今为止，几乎没有直接证据表明生物胺除了通过触发第二信使的酶促产生之外，还产生细胞内反应。我们对龙虾嗅觉受体神经元的电生理学研究现在表明，一种生物胺，组胺，可以直接控制离子通道。该通道对 1 μM 或更高的组胺浓度有反应，主要可渗透 Cl-，在去极化电位下更活跃，并且在美洲龙虾中具有 44 pS 的电导，在加勒比龙虾中具有 66 pS 的电导。这种配体门控通道在嗅觉受体神经元中的表达意味着这些神经元是调节或反馈过程的目标。
Biogenic amines mediate types of intercellular communication in multicellular organisms. Heretofore, little direct evidence has indicated that biogenic amines produce intracellular responses other than by triggering the enzymatic production of second messengers. Our electrophysiological studies of lobster olfactory receptor neurons now reveal that one biogenic amine, histamine, can directly gate an ion channel. The channel responds to histamine concentrations of 1 .mu.M or more, is permeable primarily to Cl-, is more active at depolarized potentials, and has a conductance of 44 pS in the American lobster and 66 pS in the Caribbean spiny lobster. The expression of this ligand-gated channel in olfactory receptor neurons implies that these neurons are targets of a regulatory or feedback process.