Genetic and antigenic relatedness of human and animal strains of antigenically distinct rotaviruses.
Genetic and antigenic relatedness of human and animal strains of antigenically distinct rotaviruses.
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抗原不同的轮状病毒的人类和动物株的遗传和抗原相关性。
DOI：
10.1093/infdis/154.6.972
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Yolken,RH
中科院分区：
文献类型：
--
作者：
Eiden,J;Vonderfecht,S;Theil,K;Torres-Medina,A;Yolken,RH
我们使用核酸杂交和酶和免疫荧光试验来检查抗原性不同的轮状病毒（ADRV）的人类和动物株的相关性。从马里兰州的巴尔的摩的大鼠和人中分离的ADRV显示与牛和猪B组轮状病毒株密切相关。还发现与中国胃肠炎流行相关的人B组轮状病毒与美国大鼠中传代的ADRV具有相同的抗原决定簇和基因组序列同源性。因此，B组轮状病毒的密切相关株似乎感染广泛分离的地理区域中的人类和动物群体。
We used nucleic-acid hybridization and enzymatic and immunofluorescence assays to examine the relatedness of human and animal strains of antigenically distinct rotaviruses (ADRVs). ADRVs isolated from rats and humans in Baltimore, Maryland, were shown to be closely related to bovine and porcine strains of group B rotavirus. A human group B rotavirus associated with epidemics of gastroenteritis in China was also found to share antigenic determinants and genome sequence homology with ADRVs passaged in rats in the United States. Closely related strains of group B rotavirus thus appear to infect human and animal populations in widely separated geographic areas.