Survival in epithelial ovarian cancer patients with prior breast cancer
Survival in epithelial ovarian cancer patients with prior breast cancer
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DOI：
10.1093/aje/152.6.528
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发表时间：
2000-09-15
影响因子：
5
通讯作者：
Oakley-Girvan, I
中科院分区：
文献类型：
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作者：
McGuire, V;Whittemore, AS;Oakley-Girvan, I
与没有这些突变的卵巢癌患者相比，携带生殖系BRCA1突变的卵巢癌患者可能会提高生存率。为了评估这一假设，作者比较了有乳腺癌病史和无乳腺癌病史的卵巢癌患者的生存率。具体来说，他们使用了基于人群的美国监测，流行病学和最终结果（SEER）计划的数据来评估有和没有乳腺癌病史的卵巢癌患者的卵巢癌死亡时间。所有25，637名白色女性在1973年至1995年期间在SEER登记中被诊断为浸润性上皮性卵巢癌。其中，824名女性曾被诊断为乳腺癌。经年龄和卵巢癌诊断阶段调整后，既往患有乳腺癌的女性的卵巢癌死亡率显著低于仅患有卵巢癌的女性。生存优势在老年妇女和诊断时卵巢癌较晚期的妇女中最为明显。这些结果间接支持了先前BRCA1突变携带者卵巢癌生存率提高的研究结果。
Ovarian cancer patients who carry germ-line BRCA1 mutations may have improved survival compared with ovarian cancer patients without these mutations. To evaluate this hypothesis, the authors compared survival in ovarian cancer patients who had a history of prior breast cancer with that of patients without such a history. Specifically, they used data from the population-based US Surveillance, Epidemiology, and End Results (SEER) Program to assess time to death from ovarian cancer among ovarian cancer patients with and without a prior breast cancer. All 25,637 White women diagnosed with invasive epithelial ovarian cancer in SEER registries between 1973 and 1995 were included. Of these, 824 women had had a prior breast cancer diagnosis. The ovarian cancer death rate among women with prior breast cancer was significantly lower than that of women with ovarian cancer only, adjusted for age and stage at ovarian cancer diagnosis. The survival advantage was most pronounced among older women and among those whose ovarian cancers were more advanced at the time of diagnosis. These results lend indirect support to prior findings of improved ovarian cancer survival in BRCA1 mutation carriers.