Biliverdin administration prevents the formation of intimal hyperplasia induced by vascular injury
Biliverdin administration prevents the formation of intimal hyperplasia induced by vascular injury
复制标题
DOI：
10.1161/circulationaha.104.509778
复制
发表时间：
2005-07-26
期刊：
影响因子：
37.8
通讯作者：
Kanno, S
中科院分区：
文献类型：
--
作者：
Nakao, A;Murase, N;Kanno, S
背景-自体静脉移植和球囊血管成形术仍然普遍用于动脉重建手术。他们的成功受到内膜增生（IH）发展的限制。胆绿素（BVD）是血红素降解的副产物之一，具有很强的抗氧化和降血脂作用。我们假设，BVD管理将保护血管组织对vascularinjure.Methods和结果-对IH血管损伤后的BVD管理的影响进行了分析，在动脉化静脉移植模型和球囊损伤模型大鼠。与未使用BVD的模型相比，BVD处理显著抑制了两种模型中IH的发展。BVD治疗抑制IH发展的机制可能包括减少c-Jun NH 2末端激酶活化和防止内皮细胞凋亡。BVD也抑制血管平滑肌细胞在体外的迁移。结论- BVD管理防止IH与动脉化静脉移植血管病变或球囊血管成形术诱导的血管损伤。这些结果表明，外源性BVD给药的治疗方案可提供有效的治疗辅助手段，以促进血管损伤的实验性治疗向临床转移。
Background - Autologous vein grafts and balloon angioplasty are still commonly used for arterial reconstructive procedures. Their success is limited by the development of intimal hyperplasia (IH). Biliverdin (BVD), one of the by-products of heme degradation, has been shown to have potent antioxidant and antiinflammatory effects. We hypothesized that BVD administration would protect vascular tissue against vascular injury.Methods and Results - The effects of BVD administration against IH after vascular injury were analyzed in an arterialized vein graft model and a balloon injury model in rats. BVD treatment significantly suppressed the development of IH in both models compared with those without BVD. The mechanisms by which BVD treatment inhibits IH development might include decreasing c-Jun NH2 terminal kinase activation and preventing apoptosis of endothelial cells. BVD also suppressed vascular smooth muscle cell migration in vitro.Conclusions - BVD administration prevented IH associated with arterialized vein graft vasculopathy or balloon angioplasty - induced vessel injury. These results suggest that a treatment regimen with exogenous BVD administration could provide an effective therapeutic adjunct to facilitate transfer of experimental treatments for vascular injury to the clinic.