Obesity and risk of respiratory tract infections: results of an infection-diary based cohort study
Obesity and risk of respiratory tract infections: results of an infection-diary based cohort study
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DOI：
10.1186/s12889-018-5172-8
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发表时间：
2018-02-20
影响因子：
4.5
通讯作者：
Nieters, Alexandra
中科院分区：
文献类型：
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作者：
Maccioni, Livia;Weber, Susanne;Nieters, Alexandra
背景：呼吸道感染（RTI）是一个主要的发病因素，在很大程度上有助于医疗保健费用和个人的生活质量。本研究的目的是测试肥胖（BMI>= 30 kg/m2）是否是德国成年人群中经常发生呼吸道感染的危险因素之一。方法：我们从德国的一项关于呼吸道感染的横断面调查中招募了1455名18 - 70岁的个体，并邀请他们在日记中自我报告连续三个冬/春季节发生呼吸道感染的事件。RTIs报告在这18个月和总结措施加起来个人RTIs是interests.Results的结果：与正常体重的个人相比，肥胖的个人报告的频率一贯较高的上，下RTIs和主要下降在上10%组的日记sumsore加起来10个不同的RTI症状随着时间的推移。肥胖与低RTI（调整OR = 2.02，95%CI = 1.36 - 3.00）和高RTI（调整OR = 1.55，95%CI = 1.22 - 1.96）均相关。调整人口统计学和生活方式变量对OR的影响很小。分层分析表明，一个更强的关联，为妇女和影响修改体育活动和饮食习惯. Conclusions：我们确认肥胖与感染负担的关联，并提出证据，推定的相互作用与体育活动和饮食模式。
Background: Respiratory tract infections (RTIs) are a major morbidity factor contributing largely to health care costs and individual quality of life. The aim of the study was to test whether obesity (BMI >= 30 kg/m(2)) is one of the risk factors underlying frequent RTIs in the German adult population.Methods: We recruited 1455 individuals between 18 to 70 years from a cross-sectional survey on airway infections in Germany and invited them to self-report in diaries incident RTIs experienced during three consecutive winter/spring seasons. RTIs reported in these 18 months and summary measures adding-up individual RTIs were the outcomes of interest.Results: Compared to individuals with normal weight, obese individuals reported a consistently higher frequency of upper and lower RTIs and predominantly fell in the upper 10% group of a diary sumscore adding-up 10 different RTI symptoms over time. Obesity was associated both with lower RTIs (adjustedOR = 2.02, 95% CI = 1.36-3.00) and upper RTIs (adjustedOR = 1.55, 95% CI = 1.22-1.96). Adjusting for demographic and lifestyle variables did only marginally affect ORs. Stratified analyses suggested a stronger association for women and effect modifications by sports activity and dietary habits.Conclusions: We confirm the association of obesity with infection burden and present evidence for putative interaction with sports activity and dietary patterns.