Acupuncture to reduce nausea during chemotherapy treatment of rheumatic diseases
Acupuncture to reduce nausea during chemotherapy treatment of rheumatic diseases
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DOI：
10.1093/rheumatology/keg312
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发表时间：
2003-10-01
期刊：
影响因子：
5.5
通讯作者：
Kreuter, M
中科院分区：
文献类型：
--
作者：
Josefson, A;Kreuter, M
Objective.研究针刺联合昂丹司琼治疗是否能减少风湿性疾病患者输注环磷酰胺引起的恶心呕吐。39例患者采用针刺PC 6穴和/或耳穴治疗，以减轻恶心呕吐。患者报告了化疗开始时以及4、8、24、48和72小时后恶心的严重程度和呕吐次数。结果。与单用昂丹司琼相比，针刺-昂丹司琼联合治疗显著降低了受试者在第一次治疗后24和48 h的恶心严重程度和呕吐次数（恶心：P < 0.0001;呕吐：P < 0.0035）。末次针刺后48和72 h的恶心反应与对照组无显著性差异（P> 0.0080）。24 ~ 48 h后两组比较，恶心、呕吐发生率差异无统计学意义（P> 0.0001，P < 0.0003，P < 0.0007）。我们的研究结果清楚地表明，联合治疗与针灸和昂丹司琼减少化疗引起的恶心的严重程度和持续时间，以及发作的呕吐的数量相比，单独昂丹司琼治疗，风湿性疾病的患者。
Objective. To study if acupuncture, combined with ondansetron treatment, reduces nausea and vomiting associated with cyclophosphamide infusion in patients with rheumatic diseases.Methods. Thirty-nine patients were treated with acupuncture at point PC 6 and/or in the ear to decrease nausea and vomiting. The patients reported the severity of nausea and number of bouts of vomiting at the start of chemotherapy and after 4, 8, 24, 48 and 72 h.Results. Compared with ondansetron treatment alone, the combined acupuncture-ondansetron treatment significantly decreased both the severity of nausea and the number of bouts of vomiting 24 and 48 h after the subjects had received acupuncture at the first treatment session (nausea: P < 0.0001; vomiting: P < 0.0035). Nearly the same results were seen 48 and 72 h after the subjects had had their last treatment of acupuncture (nausea P < 0.0080). Similar results were found after 24 to 48 h, when a comparison was made between two sessions close in time (nausea: P < 0.0001 after 24 h, P < 0.0003 after 48 h; vomiting: P < 0.0007).Conclusions. Our results clearly indicate that combined treatment with acupuncture and ondansetron reduces the severity and the duration of chemotherapy-induced nausea as well as the number of bouts of vomiting as compared with ondansetron therapy alone, in patients with rheumatic diseases.