Parvalbumin- and Calbindin D-28k-Immunoreactive Innervation of Orofacial Tissues in the Rat
Parvalbumin- and Calbindin D-28k-Immunoreactive Innervation of Orofacial Tissues in the Rat
复制标题
大鼠口面部组织的小清蛋白和钙结合蛋白 D-28k 免疫反应性神经支配
DOI：
10.1006/exnr.1997.6545
复制
发表时间：
1997
影响因子：
5.3
通讯作者：
T. Sugimoto
中科院分区：
文献类型：
--
作者：
H. Ichikawa;T. Sugimoto
parvalbumin和钙结合蛋白D-28 k-免疫反应（IR）神经支配的大鼠口腔颌面部组织进行了检查。唇和面部皮肤没有钙结合蛋白（CaBP）-IR神经末梢，而眶下神经和颏神经含有许多小白蛋白-IR轴突。唇和牙龈粘膜也缺乏CaBP免疫反应神经末梢。颊粘膜和切牙乳头包含有囊和无囊的终末，而硬腭粘膜不包括切牙乳头只包含无囊的终末。被包裹的末梢被发现就在上皮下面或附着在切乳头的软骨核心上。固有层中的无囊化末梢分为两种类型：简单型（无分支）和复杂型（分支）。简单末梢的神经突为直的、弯曲的或盘绕的，而复杂末梢的神经突由于分支而呈现出类似于树枝的外观。此外，腭皱含有上皮内末梢。未封装的复杂的结束在腭皱共表达小白蛋白和钙结合蛋白D-28 k-irs，而其他结束单独的小白蛋白免疫反应。翼腭神经节含有钙结合蛋白D-28 k-ir细胞周纤维，但不含ir细胞体。三叉神经节神经元的亚群共表达两种CaBP。CaBP-IR封装和未封装的结束在口腔粘膜可能包括低阈值机械感受器，而小白蛋白-IR上皮内末梢在腭粘膜可能参与伤害性感受。
Parvalbumin- and calbindin D-28k-immunoreactive (-ir) innervation was examined in orofacial tissues of the rat. Labial and facial skins were devoid of the calcium-binding protein (CaBP)-ir nerve endings, while the infraorbital and mental nerves contained numerous parvalbumin-ir axons. Labial and gingival mucosae were also devoid of the CaBP-ir nerve endings. The buccal mucosa and incisive papilla contained both encapsulated and unencapsulated endings, while the hard palate mucosa excluding the incisive papilla contained only unencapsulated endings. Encapsulated endings were found just beneath the epithelium or attached to the cartilaginous core of the incisive papilla. Unencapsulated endings in the lamina propria were subdivided into two types: simple (unramified) and complex (ramified). Neurites of simple endings were straight, curved, or coiled, while those of complex endings exhibited a bush-like appearance due to the ramification. In addition, palatal rugae contained intraepithelial endings. The unencapsulated complex endings in palatal rugae coexpressed parvalbumin- and calbindin D-28k-irs, whereas other endings were immunoreactive for parvalbumin alone. The pterygopalatine ganglion contained calbindin D-28k-ir pericellular fibers but not the ir cell bodies. A subpopulation of trigeminal ganglion neurons coexpressed both CaBPs. CaBP-ir encapsulated and unencapsulated endings in the oral mucosa probably include low-threshold mechanoreceptors, while parvalbumin-ir intraepithelial endings in the palatal mucosa may be involved in nociception.