Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1.
Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1.
复制标题
DOI：
10.1038/nsmb.2754
复制
发表时间：
2014-02
影响因子：
16.8
通讯作者：
Karlseder J
中科院分区：
文献类型：
--
作者：
O'Sullivan RJ;Arnoult N;Lackner DH;Oganesian L;Haggblom C;Corpet A;Almouzni G;Karlseder J
The mechanism of activation of the Alternative Lengthening of Telomeres (ALT) pathway of mammalian chromosome end maintenance has remained an unresolved issue. We have discovered that co-depletion of the histone chaperones ASF1a and ASF1b in human cells induced all hallmarks of ALT in both primary and cancer cells. These included the formation of ALT associated PML bodies (APBs), extra-chromosomal telomeric DNA species an elevated frequency of telomeric sister chromatid exchanges (t-SCE) events and inter-telomeric exchange of an integrated tag. The induction of ALT characteristics in this setting led to the simultaneous suppression of telomerase. We identified that ALT induction is positively regulated by RAD17 and BLM, while negatively regulated by EXO1 and DNA2. The induction of ALT phenotypes as a consequence of ASF1 depletion strongly support the hypothesis that ALT is a consequence of a histone management dysfunction.
登录
查看更多内容
影响因子：
64.8
作者：
Burrell RA;McClelland SE;Endesfelder D;Groth P;Weller MC;Shaikh N;Domingo E;Kanu N;Dewhurst SM;Gronroos E;Chew SK;Rowan AJ;Schenk A;Sheffer M;Howell M;Kschischo M;Behrens A;Helleday T;Bartek J;Tomlinson IP;Swanton C
通讯作者：
Swanton C
影响因子：
16.8
作者：
Davies, Sally L.;North, Phillip S.;Hickson, Ian D.
通讯作者：
Hickson, Ian D.
影响因子：
21.3
作者：
Chan, Kok Lung;Palmai-Pallag, Timea;Hickson, Ian D.
通讯作者：
Hickson, Ian D.
DOI：
10.1073/pnas.0907689106
发表时间：
2009-09-15
影响因子：
11.1
作者：
Draskovic, Irena;Arnoult, Nausica;Londono-Vallejo, Arturo
通讯作者：
Londono-Vallejo, Arturo
DOI：
10.1073/pnas.1113524108
发表时间：
2011-10-25
影响因子：
11.1
作者：
Hartford, Suzanne A.;Luo, Yunhai;Schimenti, John C.
通讯作者：
Schimenti, John C.