Genetic instability and darwinian selection in tumours
Genetic instability and darwinian selection in tumours
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DOI：
10.1016/s0968-0004(99)01466-8
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发表时间：
1999-12-01
影响因子：
13.8
通讯作者：
Lengauer, C
中科院分区：
文献类型：
--
作者：
Cahill, DP;Kinzler, KW;Lengauer, C
长期以来，基因不稳定一直被认为是癌症的一个基本特征。最近的工作加强了这一假设，即导致不稳定的突变改变发生在肿瘤形成的早期。随之而来的遗传不稳定性通过产生癌基因和肿瘤抑制基因的突变来推动肿瘤的进展。这些突变基因为癌细胞提供了选择性生长优势，从而导致肿瘤的克隆性生长。在这里，我们讨论了遗传不稳定性在肿瘤形成中的作用，并概述了未来需要进行的工作，以证实遗传不稳定性假说。
Genetic instability has long been hypothesized to be a cardinal feature of cancer. Recent work has strengthened the proposal that mutational alterations conferring instability occur early during tumour formation. The ensuing genetic instability drives tumour progression by generating mutations in oncogenes and tumour-suppressor genes. These mutant genes provide cancer cells with a selective growth advantage, thereby Leading to the clonal outgrowth of a tumour. Here, we discuss the role of genetic instability in tumour formation and outline future work necessary to substantiate the genetic instability hypothesis.