CELL AND ENVIRONMENT INTERACTIONS IN TUMOR MICROREGIONS - THE MULTICELL SPHEROID MODEL
CELL AND ENVIRONMENT INTERACTIONS IN TUMOR MICROREGIONS - THE MULTICELL SPHEROID MODEL
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DOI：
10.1126/science.2451290
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发表时间：
1988-04-08
期刊：
影响因子：
56.9
通讯作者：
SUTHERLAND, RM
中科院分区：
文献类型：
--
作者：
SUTHERLAND, RM
恶性肿瘤的异常血管化与异质细胞微区和环境的发展有关。多细胞球体等实验模型和各种新技术正在被用来确定这些微区域的特征，并研究细胞和微环境的相互作用。肿瘤特殊的细胞微生态影响对治疗药物的反应性，并对癌症研究的未来方向产生影响。
Abnormal vascularization of malignant tumors is associated with the development of microregions of heterogeneous cells and environments. Experimental models such as multicell spheroids and a variety of new techniques are being used to determine the characteristics of these microregions and to study the interactions of the cells and microenvironments. The special cellular microecology of tumors influences responsiveness to therapeutic agents and has implications for future directions in cancer research.