Tankyrase, a positive regulator of telomere elongation, is over expressed in human breast cancer
Tankyrase, a positive regulator of telomere elongation, is over expressed in human breast cancer
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DOI：
10.1016/j.canlet.2004.05.010
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发表时间：
2004-12-08
期刊：
影响因子：
9.7
通讯作者：
Orlando, C
中科院分区：
文献类型：
--
作者：
Gelmini, S;Poggesi, M;Orlando, C
端锚聚合酶通过与端粒蛋白结合因子TRF 1（端粒延伸的负调节因子）相互作用促进端粒延伸。我们通过实时RT-PCR检测了66例乳腺癌和配对正常组织中的端锚聚合酶mRNA。结果与hTERTmRNA表达进行比较。乳腺癌组织中端锚聚合酶的表达水平显著高于正常组织（P < 0.0001），并与孕激素受体的状态显著相关。在乳腺癌组织中，端锚聚合酶与hTERTmRNA的表达无相关性。根据我们的研究结果，端锚聚合酶的表达在乳腺癌中出现上调。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
Tankyrase promotes telomere elongation by interaction with the telomeric protein binding factor TRF1, a negative regulator of telomere extension. We measured tankyrase mRNA by real-time RT-PCR in 66 breast cancers and in paired normal tissues. Results were compared with hTERT mRNA expression. The levels of tankyrase in breast cancers were significantly higher in comparison to normal tissues (P < 0.0001) and significantly related to the status of progesterone receptors. No relationship was found between tankyrase and hTERT mRNA expression in breast cancers. According to our results, tankyrase expression appeared up regulated in breast cancers. (C) 2004 Elsevier Ireland Ltd. All rights reserved.