Cellular basis of reduced cortical reelin expression in schizophrenia
Cellular basis of reduced cortical reelin expression in schizophrenia
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DOI：
10.1176/appi.ajp.163.3.540
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发表时间：
2006-03-01
影响因子：
17.7
通讯作者：
Harrison, PJ
中科院分区：
文献类型：
--
作者：
Eastwood, SL;Harrison, PJ
目的：作者的目标是建立减少皮质reelin的表达，发生在精神分裂症的细胞起源，并将其与标记的突触pathologic.Method：原位杂交被用来量化reelin mRNA在海马结构和背外侧前额叶皮层的大脑从13例精神分裂症和12例无精神分裂症。结果：Reelin mRNA表达于第一层神经元、中间神经元和间质白色神经元。在精神分裂症患者中，海马结构中的间质白色物质神经元和前额叶皮质中的所有三种细胞类型表达较少的reelin mRNA。Reelin和突触蛋白的表达呈正相关。结论：间质白色物质神经元，推测残留的皮质亚板，有助于减少reelin mRNA在精神分裂症。reelin表达的下调可能反过来有助于疾病的突触病理学。
Objective: The authors' goals were to establish the cellular origin of the reduced cortical reelin expression that occurs in schizophrenia and to relate it to markers of synaptic pathology.Method: In situ hybridization was used to quantify reelin mRNA in the hippocampal formation and dorsolateral prefrontal cortex of brains from 13 subjects with schizophrenia and 12 subjects without schizophrenia. Results were correlated with the expression of three synaptic protein genes in the dentate gyrus.Results: Reelin mRNA was expressed by layer I neurons, interneurons, and interstitial white matter neurons. In subjects with schizophrenia, less reelin mRNA was expressed by interstitial white matter neurons in the hippocampal formation and by all three cell types in the prefrontal cortex. Reelin and synaptic protein expression correlated positively.Conclusions: Interstitial white matter neurons, presumed remnants of the cortical subplate, contribute to the reduction in reelin mRNA in schizophrenia. Down-regulation of reelin expression may in turn contribute to the synaptic pathology of the disorder.