WSsas: a web service for the annotation of functional residues through structural homologues
WSsas: a web service for the annotation of functional residues through structural homologues
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DOI：
10.1093/bioinformatics/btp116
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发表时间：
2009-05-01
期刊：
影响因子：
5.8
通讯作者：
Thornton, Janet M.
中科院分区：
文献类型：
--
作者：
Talavera, David;Laskowski, Roman A.;Thornton, Janet M.
动机：注释工具帮助科学家穿越已表征和未表征蛋白质之间的差距。用于预测蛋白质功能的工具包括预测整个蛋白质或复合物的功能的工具、注释功能结构域的工具和预测结构域内的特定残基的工具。我们已经开发了WSsas，一个Web服务，专注于注释的基本功能残基。WSSAs使用相似性搜索和成对比对将关于结合、催化和蛋白质-蛋白质相互作用残基的功能信息从解出的结构转移到查询序列。此外，WSSA还可以提供有关相关功能原子的信息。Web服务定义（WSDL）。le和Perl客户端可以在http://www.ebi.ac.uk/thornton-srv/databases/WSsas/上免费获得。
Motivation: Annotation tools help scientists to traverse the gap between characterized and uncharacterized proteins. Tools for the prediction of protein function include those which predict the function of entire proteins or complexes, those annotating functional domains and those which predict specific residues within the domain. We have developed WSsas, a web service focused on the annotation of essential functional residues. WSsas uses similarity searches and pairwise alignments to transfer functional information about binding, catalytic and protein-protein interaction residues from solved structures to query sequences. In addition, WSsas can supply information about the relevant functional atoms. The web service definition (WSDL). le and a Perl client are freely available at http://www.ebi.ac.uk/thornton-srv/databases/WSsas/.