Reliability and convergent validity of two outcome instruments for pemphigus.
Reliability and convergent validity of two outcome instruments for pemphigus.
复制标题
DOI：
10.1038/jid.2009.72
复制
发表时间：
2009-10
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
进行天疱疮多中心对照试验的一个主要障碍是缺乏有效的疾病活动评分系统。在这里，我们评估的可靠性和收敛效度的天疱疮疾病面积指数（PDAI）。一组10名皮肤科医生对15名天疱疮患者进行评分，以评估PDAI和最近描述的ABSIS（自身免疫性大疱性皮肤病强度评分）工具的评分者间和评分者内可靠性。为了评估收敛效度，这些工具也与医生的全球评估（PGA）。可靠性研究表明，PDAI和ABSIS的评定者间可靠性的类内相关系数（ICC）分别为0.76 [95% CI = 0.61-0.91]和0.77 [0.63-0.91]。这些工具在评估皮肤活动的可靠性方面差异最大，ABSIS的ICC为0.39 [0.17-0.60]，PDAI为0.86 [0.76-0.95]。评定者内重测信度显示，PDAI的ICC为0.98 [0.96-1.0]，ABSIS的ICC为0.80 [0.65-0.96]。PDAI也与PGA更密切相关。我们得出结论，PDAI是更可重复的，更好地与医生的印象程度。子集分析表明，对于这一轻度至中度疾病活动的人群，PDAI比ABSIS捕获更多的皮肤疾病变异性。
A major obstacle in performing multicenter controlled trials for pemphigus is the lack of a validated disease activity scoring system. Here we assess the reliability and convergent validity of the PDAI (pemphigus disease area index). A group of 10 dermatologists scored 15 patients with pemphigus to estimate the inter- and intra-rater reliability of the PDAI and the recently described ABSIS (autoimmune bullous skin disorder intensity score) instrument. To assess convergent validity, these tools were also correlated with the Physician’s Global Assessment (PGA). Reliability studies demonstrated an intra-class correlation coefficient (ICC) for inter-rater reliability of 0.76 [95% CI = 0.61–0.91] for the PDAI and 0.77 [0.63–0.91] for the ABSIS. The tools differed most in reliability of assessing skin activity, with an ICC of 0.39 [0.17–0.60] for the ABSIS and 0.86 [0.76–0.95] for the PDAI. Intra-rater test-retest reliability demonstrated an ICC of 0.98 [0.96–1.0] for the PDAI and 0.80 [0.65–0.96] for the ABSIS. The PDAI also correlated more closely with the PGA. We conclude that the PDAI is more reproducible and correlates better with physician impression of extent. Subset analysis suggests that for this population of mild to moderate disease activity, the PDAI captures more variability in cutaneous disease than the ABSIS.
登录
查看更多内容
影响因子：
10.3
作者：
TILINGGROSSE, S;REES, J
通讯作者：
REES, J
DOI：
10.1016/s0190-9622(03)01475-0
发表时间：
2003-11-01
影响因子：
13.8
作者：
Heald, P;Mehlmauer, M;Reich, SD
通讯作者：
Reich, SD
影响因子：
--
作者：
Charman, C;Williams, H
通讯作者：
Williams, H
影响因子：
13.8
作者：
Langley, RG;Ellis, CN
通讯作者：
Ellis, CN
影响因子：
13.8
作者：
Hundley, JL;Carroll, CL;Jorizzo, JL
通讯作者：
Jorizzo, JL