Patterns of neuropsychological impairment in MCI patients with small subcortical infarcts or hippocampal atrophy
Patterns of neuropsychological impairment in MCI patients with small subcortical infarcts or hippocampal atrophy
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DOI：
10.1017/s1355617708080831
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发表时间：
2008-07-01
影响因子：
2.6
通讯作者：
Marra, Camillo
中科院分区：
文献类型：
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作者：
Gainotti, Guido;Ferraccioli, Monica;Marra, Camillo
我们调查了是否MCI患者海马萎缩或多发性皮质下梗死表现出神经心理学模式和标志物被认为是典型的阿尔茨海默病（AD）和血管性痴呆（VD），分别。广泛的神经心理电池。对36例伴有海马萎缩的轻度认知功能障碍（MCI）患者和41例伴有多发性皮层下梗死的MCI患者进行了记忆、视觉空间和执行功能、语言、注意、实践和心理速度等测试。两组MCI患者的MMSE评分均为非常轻度的损害，且匹配良好。在伴有海马萎缩的MCI患者中观察到明显的、不成比例的严重情景记忆障碍。在患有多发性皮质下梗死的轻度认知障碍患者中观察到了一种不太具体的神经心理学特征，包括对额叶病变敏感的动作命名任务的障碍。在MCI患者中，不成比例的严重情景记忆障碍强烈指向阿尔茨海默氏症型脑病理，而执行缺陷和其他额叶症状的患病率是小血管皮质下疾病的弱得多的诊断标志。
We investigated whether MCI patients with hippocampal atrophy or multiple subcortical infarcts demonstrate neuropsychological patterns and markers considered typical of Alzheimer's disease (AD) and of vascular dementia (VD), respectively. An extensive neuropsychological battery. including tests of memory, visual-spatial and executive functions, language, attention, praxis and psychomotor speed, was administered to 36 mild cognitive impairment (MCI) patients with hippocampal atrophy and 41 MCI patients with multiple subcortical infarcts. Both groups Of MCI patients were very mildly impaired and well matched in terms of MMSE scores. A clear, disproportionately severe, episodic memory disorder was observed in MCI patients with hippocampal atrophy. A less specific neuropsychological profile, consisting of impairment on an Action Naming task that is sensitive to frontal lobe lesions, was observed in MCI patients with multiple subcortical infarcts. In MCI patients, a disproportionately severe episodic memory impairment strongly points to an Alzheimer's type brain pathology, whereas the prevalence of executive deficits and other frontal lobe symptoms are a much weaker diagnostic marker of small vessel subcortical disease.