Advances in Synthetic Biology
Advances in Synthetic Biology
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合成生物学的进展
DOI：
10.1007/978-981-15-0081-7_8
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Zarubiieva I
中科院分区：
文献类型：
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作者：
Zarubiieva I
使用核酸作为设计可编程生物分子电路的基底的想法在近四十年前首次提出;然而，到目前为止，DNA计算领域仍存在许多挑战和不确定性。本章介绍了DNA编程的历史演变沿着其最引人注目的突破，直到目前的日子，描述了基本的这些重要的理论概念，如DNA链置换和抽象化学反应网络，最后，熟悉的各种平台，在硅片合成和模拟遗传电路的读者。
The idea to use nucleic acid as a substrate for design of programmable biomolecular circuits was first introduced almost four decades ago; however, up till now, the field of DNA computing holds many challenges and uncertainties to be discovered. This chapter describes the historical evolution of DNA programming along with its most noticeable breakthroughs till the current days, describes the basics of such important theoretical concepts as DNA strand displacement and Abstract Chemical Reaction Networks, and finally, familiarises the reader with various platforms for in silico synthesis and simulation of genetic circuits.