Oral Human Papillomavirus Infection: Differences in Prevalence Between Sexes and Concordance With Genital Human Papillomavirus Infection, NHANES 2011 to 2014.
Oral Human Papillomavirus Infection: Differences in Prevalence Between Sexes and Concordance With Genital Human Papillomavirus Infection, NHANES 2011 to 2014.
复制标题
口腔人乳头瘤病毒感染：性别之间的患病率差异和与生殖器人乳头瘤病毒感染的一致性，NHANES 2011年至2014年。
DOI：
10.7326/m17-1363
复制
发表时间：
2017-11-21
影响因子：
39.2
通讯作者：
Deshmukh AA
中科院分区：
文献类型：
--
作者：
Sonawane K;Suk R;Chiao EY;Chhatwal J;Qiu P;Wilkin T;Nyitray AG;Sikora AG;Deshmukh AA
人乳头瘤病毒（HPV）阳性口咽鳞状细胞癌（OPSCC）的负担在男性中不成比例地高，但关于口腔HPV感染的性别差异患病率的经验证据有限。男性口腔和生殖器HPV感染的一致性尚不清楚。确定美国男性和女性口腔HPV感染的患病率，以及口腔和生殖器HPV感染的一致性。全国代表性调查。非收容人口。研究对象为2011-2014年全国健康与营养调查18-69岁。口腔冲洗、阴茎拭子和阴道拭子标本采用聚合酶链反应和类型特异性杂交进行评估。口腔HPV在男性和女性中的总体患病率分别为11.5%（相当于全国1100万男性）和3.2%（320万）。高危口腔HPV （HR-HPV）在男性中的患病率（7.3%）高于女性（1.4%）。口腔HPV-16在男性（1.8%）中的发病率是女性（0.3%）的6倍，即170万男性比27万女性。在报告有同性性伴侣的男性和女性中，HR-HPV感染率分别为12.7%和3.6%。特别是，在报告有≥2个同性口交伴侣的男性中，患病率为22.2%。并发生殖器HPV感染的男性的口腔HPV患病率（19.3%）是未感染生殖器HPV的男性（4.4%）的4倍。口交伴侣的性别和终生数量与总体HPV、HR-HPV、一致性总体HPV和一致性HR-HPV感染相关。性行为是自我报告的。口腔HPV感染在美国男性中很常见。我们的研究结果为指导未来OPSCC预防工作以对抗这种疾病提供了一些政策意义。
The burden of human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma (OPSCC) is disproportionately high among men, yet empirical evidence regarding the differential prevalence of oral HPV infection by gender is limited. Concordance of oral and genital HPV infection among men is unknown. To determine the prevalence of oral HPV infection, and concordance of oral and genital HPV infection among US men and women. Nationally representative survey. Civilian noninstitutionalized population. Participants aged 18–69 years from the National Health and Nutritional Examination Survey (2011–2014). Oral rinse, penile swab, and vaginal swab specimens were evaluated using polymerase chain reaction followed by type-specific hybridization. The overall prevalence of oral HPV among men and women was 11.5% (equating to 11 million men nationwide) and 3.2% (3.2 million), respectively. High-risk oral HPV (HR-HPV) prevalence was higher among men (7.3%) than in women (1.4%). Oral HPV-16 was 6-times more common in men (1.8%) than in women (0.3%), i.e., 1.7 million men compared with 0.27 million women. Among men and women who reported having same gender sex partners, prevalence of HR-HPV infection was 12.7% and 3.6%, respectively. Particularly, among men who reported having ≥2 same gender oral sex partners, prevalence was 22.2%. Oral HPV prevalence among men with concurrent genital HPV infection was 4-fold greater (19.3%) compared to men without genital HPV infection (4.4%). Gender and lifetime number of oral sex partners were associated with overall HPV, HR-HPV, concordant overall HPV, and concordant HR-HPV infection. Sexual behaviors were self-reported. Oral HPV infection is common among US men. Our findings provide several policy implications to guide future OPSCC prevention efforts to combat this disease.